Gene Duplicates: Agents of Robustness or Fragility?

A recent analysis of paralog deletion in yeast has shown that functional compensation and dependency occur equally. While theory predicts that compensation produces robustness, the authors hypothesized that stabilization of one paralogous protein through interaction with its copy could explain depen...

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Bibliographic Details
Published in:Trends in genetics 2017-06, Vol.33 (6), p.377-379
Main Author: Veitia, Reiner A
Format: Article
Language:English
Subjects:
Dosage Compensation, Genetic - genetics
Evolution, Molecular
Gene Deletion
gene duplication
Gene Duplication - genetics
Medical Education
Models, Genetic
neofunctionalization
paralogs
Proteins - genetics
protein–protein interactions
Saccharomyces cerevisiae - genetics
Sequence Homology, Nucleic Acid
subfunctionalization
whole genome duplication
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Summary:A recent analysis of paralog deletion in yeast has shown that functional compensation and dependency occur equally. While theory predicts that compensation produces robustness, the authors hypothesized that stabilization of one paralogous protein through interaction with its copy could explain dependency. Here, we provide alternative explanations, such as selection for increased protein dosage and hypofunctionalization.
ISSN:0168-9525
DOI:10.1016/j.tig.2017.03.006