Humoral primary immunodeficiency diseases: clinical overview and chest high-resolution computed tomography (HRCT) features in the adult population

Humoral primary immunodeficiency diseases (hPIDs) are a heterogeneous group of hereditary disorders resulting in abnormal susceptibility to infections of the sinopulmonary tract. Some of these conditions (e.g., common variable immunodeficiency disorders [CVID]) imply a number of non-infectious thora...

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Bibliographic Details
Published in:Clinical radiology 2017-07, Vol.72 (7), p.534-542
Main Authors: Cereser, L, Girometti, R, d'Angelo, P, De Carli, M, De Pellegrin, A, Zuiani, C
Format: Article
Language:English
Subjects:
Adult
Humans
Immunity, Humoral
Immunologic Deficiency Syndromes - diagnostic imaging
Radiography, Thoracic
Radiology
Tomography, X-Ray Computed - methods
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Summary:Humoral primary immunodeficiency diseases (hPIDs) are a heterogeneous group of hereditary disorders resulting in abnormal susceptibility to infections of the sinopulmonary tract. Some of these conditions (e.g., common variable immunodeficiency disorders [CVID]) imply a number of non-infectious thoracic complications such as non-infectious airway disorders, diffuse lung parenchymal diseases, and neoplasms. Chest high-resolution computed tomography (HRCT) is a key imaging tool to characterise and quantify the extent of underlying thoracic involvement, as well as to direct and monitor treatment. The aims of this review are to provide a brief clinical overview of hPIDs and describe the related chest HRCT imaging features in the adult population, with a special focus on CVID and its complications.
ISSN:0009-9260
1365-229X
DOI:10.1016/j.crad.2017.03.018