Assessment of physical fatigability and fatigue perception in myasthenia gravis

ABSTRACT Introduction Fatigue includes both performance fatigability and fatigue perception. Methods In 32 stable patients with generalized myasthenia gravis (MG) and 17 controls, time‐dependent physical performance was assessed by the arm movement test (AMT) and 6‐minute walk test (6MWT). MG patien...

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Bibliographic Details
Published in:Muscle & nerve 2017-05, Vol.55 (5), p.657-663
Main Authors: Jordan, Berit, Mehl, Theresa, Schweden, Tabea L.K., Menge, Uwe, Zierz, Stephan
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
antibody
Autoantibodies - blood
Exercise Test
fatigability
Fatigue - immunology
Fatigue - physiopathology
fatigue perception
Female
Humans
linear trend
Male
Middle Aged
Muscle Fatigue - physiology
myasthenia gravis
Myasthenia Gravis - immunology
Myasthenia Gravis - physiopathology
pathologic decrement
Perception - physiology
Physical Endurance - physiology
physical fatigue
Receptors, Cholinergic - immunology
Surveys and Questionnaires
weakness
Young Adult
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Summary:ABSTRACT Introduction Fatigue includes both performance fatigability and fatigue perception. Methods In 32 stable patients with generalized myasthenia gravis (MG) and 17 controls, time‐dependent physical performance was assessed by the arm movement test (AMT) and 6‐minute walk test (6MWT). MG patients presented with low quantitative MG scores (mean 0.5, SD 0.5) and without pathologic decrement. Fatigability was based on calculation of linear trend (LT) reflecting dynamic performance within subsequent constant time intervals. Perception of physical fatigue was analyzed using fatigue questionnaires. Results MG patients showed a negative LT in both AMT and 6MWT, significantly differing from stable performance in controls. LT inversely correlated with elevation of acetylcholine receptor antibodies (r = −0.59, P 
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.25386