Tolerance of neonatal rat brain to acute hyperammonemia

The aim of the present work was to study the effects of hyperammonemia on brain energy metabolism in neonatal rats. Rats were rendered hyperammonemic by ammonium acetate administration. This decreased brain ATP concentrations but enhanced brain ammonia and lactate levels in both adult and neonatal r...

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Published in:Brain research 2003-05, Vol.973 (1), p.31-38
Main Authors: Garcı&#x0301, a, M.Victoria, López-Mediavilla, Casilda, Juanes de la Peña, Marı&#x0301, a C., Medina, José M.
Format: Article
Language:English
Subjects:
Acute Disease
Adenosine Triphosphate - metabolism
Age Factors
Ammonia - metabolism
Ammonia - toxicity
Animals
Animals, Newborn
Biological and medical sciences
Brain - drug effects
Brain - metabolism
Errors of metabolism
Female
Glutamate
Glutamic Acid - metabolism
Glutamine
Hyperammonemia
Hyperammonemia - chemically induced
Hyperammonemia - metabolism
Lactic Acid - metabolism
Male
Medical sciences
Metabolic diseases
Miscellaneous hereditary metabolic disorders
Mitochondria
Neonate
Rats
Rats, Wistar
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description The aim of the present work was to study the effects of hyperammonemia on brain energy metabolism in neonatal rats. Rats were rendered hyperammonemic by ammonium acetate administration. This decreased brain ATP concentrations but enhanced brain ammonia and lactate levels in both adult and neonatal rats. In adult rats, the decrease in brain ATP concentrations was accompanied by a plunge in the respiratory control rate (RCR) of brain mitochondria. However, the ammonia-induced effect on RCR was not observed in neonatal rats, suggesting that the fall in ATP levels observed in neonatal rats would not be due to an impairment of mitochondrial respiratory efficiency. However, in neonatal rats the increase in blood and brain ammonia concentrations did not change brain glutamate concentrations but decreased glutamine contents. These results may be of relevance for the understanding of the resistance of neonatal rats observed in this work to acute ammonia toxicity
doi_str_mv 10.1016/S0006-8993(03)02529-0
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source Elsevier:Jisc Collections:Elsevier Read and Publish Agreement 2022-2024:Freedom Collection (Reading list)
subjects Acute Disease
Adenosine Triphosphate - metabolism
Age Factors
Ammonia - metabolism
Ammonia - toxicity
Animals
Animals, Newborn
Biological and medical sciences
Brain - drug effects
Brain - metabolism
Errors of metabolism
Female
Glutamate
Glutamic Acid - metabolism
Glutamine
Hyperammonemia
Hyperammonemia - chemically induced
Hyperammonemia - metabolism
Lactic Acid - metabolism
Male
Medical sciences
Metabolic diseases
Miscellaneous hereditary metabolic disorders
Mitochondria
Neonate
Rats
Rats, Wistar
title Tolerance of neonatal rat brain to acute hyperammonemia
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