Differential Hepatic Gene Expression Profile and Histone Modification After Acute or Chronic Hyperthyroidism or During Remission

In acute and chronic hyperthyroid patients, clinical symptoms may not always reflect their thyroid hormone status. After normalization of serum thyroid hormone concentrations in these patients, some symptoms caused by hyperthyroidism may remain unchanged (1). Even in subclinical hyperthyroid patient...

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Bibliographic Details
Published in:Endocrinology (Philadelphia) 2016-04, Vol.157 (4), p.1326-1327
Main Author: Koibuchi, Noriyuki
Format: Article
Language:English
Subjects:
Animals
Gene expression
Gene Expression Profiling - methods
Histones
Hyperthyroidism
Liver - metabolism
Male
Remission
Transcriptome - drug effects
Triiodothyronine - pharmacology
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Summary:In acute and chronic hyperthyroid patients, clinical symptoms may not always reflect their thyroid hormone status. After normalization of serum thyroid hormone concentrations in these patients, some symptoms caused by hyperthyroidism may remain unchanged (1). Even in subclinical hyperthyroid patients, functional recovery after restoration to euthyroidism is sometimes incomplete (2). The underlying mechanisms of such incomplete recovery are not yet fully understood. Indeed, functional adaptation or irreversible alteration may be induced during exposure to excess thyroid hormone.
ISSN:0013-7227
1945-7170
DOI:10.1210/en.2016-1110