Sleep and Parkinson's disease: A review of case-control polysomnography studies

The link between Parkinson's disease (PD) and certain primary sleep disorders has yet to be clarified. We performed a systematic review of case‐control polysomnography studies to evaluate the relationship between PD and sleep disorders. A PubMed literature search and bibliography review yielded...

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Bibliographic Details
Published in:Movement disorders 2012-12, Vol.27 (14), p.1729-1737
Main Authors: Peeraully, Tasneem, Yong, Ming-Hui, Chokroverty, Sudhansu, Tan, Eng-King
Format: Article
Language:English
Subjects:
Biological and medical sciences
Case-Control Studies
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Humans
Medical sciences
Movement disorders
Neurology
obstructive sleep apnea
Parkinson Disease - complications
Parkinson Disease - physiopathology
Parkinson's
periodic leg movements
polysomnography
Polysomnography - methods
REM behavior disorder
sleep
Sleep - physiology
Sleep Wake Disorders - etiology
Sleep Wake Disorders - physiopathology
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Summary:The link between Parkinson's disease (PD) and certain primary sleep disorders has yet to be clarified. We performed a systematic review of case‐control polysomnography studies to evaluate the relationship between PD and sleep disorders. A PubMed literature search and bibliography review yielded 15 case‐control polysomnography studies in patients with PD. Studies differed by recruitment methods, duration of polysomnography monitoring, and sleep parameters measured. Subjective sleepiness was greater in patients than controls (50%–66% vs 2.9%–12%) despite lack of objective increase in daytime sleepiness by mean sleep latency testing. The 4 case‐control polysomnography studies investigating rapid eye movement behavior disorder support a higher prevalence in PD (0%–47% vs 0%–1.8% in controls), although differences in diagnostic criteria hamper interpretation. The preponderance of evidence did not support an increased incidence of obstructive sleep apnea (27%–60% vs 13%–65%) or periodic leg movements of sleep in patients compared to controls. Adequately powered, prospective studies with uniform methodology and healthy controls are needed to further address the association and pathophysiological significance between PD and sleep problems. © 2012 Movement Disorder Society
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.25197