In vitro activity of an essential oil against Leishmania donovani

The in vitro antileishmanial effect of the essential oil from Chenopodium ambrosioides against Leishmania donovani was investigated. The product showed significant activity against promastigotes and amastigotes, with a 50% effective concentration of 4.45 and 5.1 μg/mL, respectively. The essential oi...

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Bibliographic Details
Published in:Phytotherapy research 2007-11, Vol.21 (11), p.1055-1058
Main Authors: Monzote, L, García, M, Montalvo, A.M, Scull, R, Miranda, M, Abreu, J
Format: Article
Language:English
Subjects:
amastigote
Animals
Biological and medical sciences
Chenopodium ambrosioides
Chenopodium ambrosioides - chemistry
General pharmacology
Leishmania donovani
Leishmania donovani - drug effects
Leishmaniasis, Visceral - parasitology
macrophage
Medical sciences
Oils, Volatile - pharmacology
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
promastigote
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Summary:The in vitro antileishmanial effect of the essential oil from Chenopodium ambrosioides against Leishmania donovani was investigated. The product showed significant activity against promastigotes and amastigotes, with a 50% effective concentration of 4.45 and 5.1 μg/mL, respectively. The essential oil caused an irreversible inhibition of the growth of promastigotes after a treatment with 100 or 10 μg/mL for 1 or 24 h, respectively. The phagocytic activity of the macrophages was preserved at a concentration toxic to the parasite. The essential oil from C. ambrosioides may be a potential candidate drug to development a new agent to combat this parasitic disease. Copyright © 2007 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.2210