Methyl Jasmonate Ameliorates Testosterone Propionate‐induced Prostatic Hyperplasia in Castrated Wistar Rats

Benign prostate hyperplasia (BPH) is a progressive disease that is related to age. Known therapeutic agents used in the treatment of BPH are associated with toxicity. Therefore, chemoprevention could be an effective approach. We investigated the ameliorative effects of methyl jasmonate (MeJA) in tes...

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Bibliographic Details
Published in:Phytotherapy research 2017-04, Vol.31 (4), p.647-656
Main Authors: Akanni, Olubukola Oyebimpe, Abiola, Olusoji John, Adaramoye, Oluwatosin Adekunle
Format: Article
Language:English
Subjects:
Acetates - chemistry
Animals
benign prostate hyperplasia
Cyclopentanes - chemistry
Humans
Male
methyl jasmonate
oxidative stress
Oxylipins - chemistry
Plant Extracts - chemistry
prostate‐specific antigen
Prostatic Hyperplasia - drug therapy
Rats
Rats, Wistar
Testosterone - chemistry
Testosterone Propionate - chemistry
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Summary:Benign prostate hyperplasia (BPH) is a progressive disease that is related to age. Known therapeutic agents used in the treatment of BPH are associated with toxicity. Therefore, chemoprevention could be an effective approach. We investigated the ameliorative effects of methyl jasmonate (MeJA) in testosterone propionate (TP)‐induced BPH in castrated rats. Castration was performed by removing both testes through the scrotum sack under ketamine anesthesia. Rats were assigned into seven groups of seven animals each: non‐castrated control, castrated control, castrated rats that received TP, castrated rats that received TP and MeJA, castrated rats that received TP and finasteride, castrated rats that received MeJA, and castrated rats that received finasteride. Results indicate that BPH rats had significantly (p 
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.5778