Abnormalities in serum biomarkers correlate with lower cardiac index in the Fontan population

Fontan survivors have depressed cardiac index that worsens over time. Serum biomarker measurement is minimally invasive, rapid, widely available, and may be useful for serial monitoring. The purpose of this study was to identify biomarkers that correlate with lower cardiac index in Fontan patients....

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Bibliographic Details
Published in:Cardiology in the young 2017-01, Vol.27 (1), p.59-68
Main Authors: Marino, Bradley S., Goldberg, David J., Dorfman, Adam L., King, Eileen, Kalkwarf, Heidi, Zemel, Babette S., Smith, Margaret, Pratt, Jesse, Fogel, Mark A., Shillingford, Amanda J., Deal, Barbara J., John, Anitha S., Goldberg, Caren S., Hoffman, Timothy M., Jacobs, Marshall L., Lisec, Asher, Finan, Susan, Kochilas, Lazaros K., Pawlowski, Thomas W., Campbell, Kathleen, Joiner, Clinton, Goldstein, Stuart L., Stephens, Paul, Chin, Alvin J.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biomarkers - blood
Cardiac Output - physiology
Child
Female
Follow-Up Studies
Fontan Procedure - methods
Heart Defects, Congenital - blood
Heart Defects, Congenital - physiopathology
Heart Defects, Congenital - surgery
Humans
Male
Monitoring, Physiologic - methods
Original Articles
Prognosis
Prospective Studies
ROC Curve
Young Adult
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Summary:Fontan survivors have depressed cardiac index that worsens over time. Serum biomarker measurement is minimally invasive, rapid, widely available, and may be useful for serial monitoring. The purpose of this study was to identify biomarkers that correlate with lower cardiac index in Fontan patients. Methods and results This study was a multi-centre case series assessing the correlations between biomarkers and cardiac magnetic resonance-derived cardiac index in Fontan patients ⩾6 years of age with biochemical and haematopoietic biomarkers obtained ±12 months from cardiac magnetic resonance. Medical history and biomarker values were obtained by chart review. Spearman's Rank correlation assessed associations between biomarker z-scores and cardiac index. Biomarkers with significant correlations had receiver operating characteristic curves and area under the curve estimated. In total, 97 cardiac magnetic resonances in 87 patients met inclusion criteria: median age at cardiac magnetic resonance was 15 (6-33) years. Significant correlations were found between cardiac index and total alkaline phosphatase (-0.26, p=0.04), estimated creatinine clearance (0.26, p=0.02), and mean corpuscular volume (-0.32, p
ISSN:1047-9511
1467-1107
DOI:10.1017/S1047951116000093