Lycopene Consumption and Risk of Colorectal Cancer: A Meta-Analysis of Observational Studies

A number of epidemiological studies have explored the association between lycopene or lycopene-rich food intake and the risk of colorectal cancer, but the results of these studies have not been consistent. We conducted a systematic review and meta-analysis of studies published in the PubMed and EMBA...

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Bibliographic Details
Published in:Nutrition and cancer 2016-10, Vol.68 (7), p.1083-1096
Main Authors: Wang, Xin, Yang, Hui-Hui, Liu, Yan, Zhou, Quan, Chen, Zi-Hua
Format: Article
Language:English
Subjects:
Anticarcinogenic Agents - therapeutic use
Antioxidants - therapeutic use
Carotenoids - therapeutic use
Case-Control Studies
Cohort Studies
Colorectal cancer
Colorectal Neoplasms - epidemiology
Colorectal Neoplasms - prevention & control
Dietary Supplements
Evidence-Based Medicine
Health risk assessment
Healthy Diet
Humans
Meta-analysis
Observational Studies as Topic
Reproducibility of Results
Risk
Studies
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Summary:A number of epidemiological studies have explored the association between lycopene or lycopene-rich food intake and the risk of colorectal cancer, but the results of these studies have not been consistent. We conducted a systematic review and meta-analysis of studies published in the PubMed and EMBASE databases to quantitatively assess the association between lycopene consumption and the risk of colorectal cancer. A total of 15 studies were included in the meta-analysis, and the summary relative risk (RR) for highest versus lowest category indicated no significant association between lycopene consumption and the risk of colorectal cancer [RR = 0.94, 95% confidence interval (CI): 0.80-1.10]. However, a significant inverse association was observed between lycopene consumption and the site of cancer in the colon (RR = 0.88, 95% CI: 0.81-0.96). We also found that the incidence of colon cancer and lycopene intake did not exhibit dose-response relationships. The Grades of Recommendations Assessment, Development and Evaluation (GRADE) quality in our study was very low. In conclusion, this meta-analysis indicates that lycopene consumption is not associated with the risk of colorectal cancer. Further research will be needed in this area to provide conclusive evidence.
ISSN:0163-5581
1532-7914
DOI:10.1080/01635581.2016.1206579