Adipokines may mediate the relationship between resting metabolic rates and bone mineral densities in obese women

• Published in: Osteoporosis international 2017-05, Vol.28 (5), p.1619-1629
• Main Authors: Moradi, S., Mirzaei, K., Abdurahman, A. A., Keshavarz, S. A.
• Format: Article
• Language: English
• Subjects: Adipokines - blood; Adipokines - physiology; Adolescent; Adult; Aged; Angiopoietin; Anthropometry - methods; Basal Metabolism - physiology; Body composition; Body Composition - physiology; Body fat; Body mass index; Body weight; Bone composition; Bone density; Bone Density - physiology; Bone loss; Bone mineral density; Cross-Sectional Studies; Cytokines - blood; Diet - statistics & numerical data; Dietary intake; Endocrinology; Energy expenditure; Enzyme-linked immunosorbent assay; Female; GPI-Linked Proteins - blood; Humans; Lectins - blood; Leptin; Medicine; Medicine & Public Health; Metabolic rate; Metabolism; Middle Aged; Obesity; Obesity - blood; Obesity - physiopathology; Original Article; Orthopedics; Osteoporosis; Retinol-binding protein; Rheumatology; Tumor necrosis factor-α; Vitamin A; Young Adult
• ISSN: 0937-941X; 1433-2965
• DOI: 10.1007/s00198-017-3914-6

Summary The researchers sought to test the possible link between resting metabolic rate and bone mineral density through four adipokines. Participants with lower resting metabolic rate (RMR) per kilogram demonstrated higher total bone mineral density (BMD), total T-score, and total Z-score. Omentin-1 had a mediatory effect on the relationship between RMR/kg of body weight and bone parameters. Introduction The previous results of studies regarding the links between obesity and bone health are controversial. For this reason, the researchers sought to test the possible link between RMR and BMD through the following four adipokines: vaspin, retinol binding protein 4, angiopoietin-like 6 (ANGPL6), and omentin-1. Methods We enrolled 312 obese Iranian women (30 ≤ body mass index