Elevated intraocular pressure increases melatonin levels in the aqueous humour

Purpose To study the levels of melatonin in the aqueous humour of normotensive and hypertensive intraocular pressure (IOP) patients and to compare them to an animal model of glaucoma. Methods A total of 37 eyes of 37 patients who underwent cataract surgery were included in the study and were divided...

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Bibliographic Details
Published in:Acta ophthalmologica (Oxford, England) England), 2017-05, Vol.95 (3), p.e185-e189
Main Authors: Alkozi, Hanan, Sánchez‐Naves, Juan, Lara, Maria Jesús Perez, Carracedo, Gonzalo, Fonseca, Begoña, Martinez‐Aguila, Alejandro, Pintor, Jesús
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Animals
Aqueous Humor - metabolism
aqueous humour
Biomarkers - metabolism
Chromatography, High Pressure Liquid
Disease Models, Animal
Female
glaucoma
Glaucoma - metabolism
Glaucoma - physiopathology
high‐performance liquid chromatography
Humans
Intraocular Pressure - physiology
Male
melatonin
Melatonin - metabolism
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Middle Aged
Ocular Hypertension - metabolism
Ocular Hypertension - physiopathology
Ophthalmology
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Summary:Purpose To study the levels of melatonin in the aqueous humour of normotensive and hypertensive intraocular pressure (IOP) patients and to compare them to an animal model of glaucoma. Methods A total of 37 eyes of 37 patients who underwent cataract surgery were included in the study and were divided into normotensive patients, with IOP below 21 mmHg (n = 23), and hypertensive patients, with IOP > 21 mmHg (n = 14). Glaucomatous DBA/2J (n = 6) and control C57BL/6J (n = 6) mice presenting 3 and 12 months of age for each strain were also used. Human and mice aqueous humours were aspirated using a 30‐gauge Rycroft cannula on a tuberculin syringe and further processed to quantify melatonin by high‐performance liquid chromatography analysis. Results Melatonin levels in normotensive patients (IOP below 21 mmHg) presented values as medians (first quartile; third quartile) of 14.62 (5.38;37.99) ng/ml (n = 23), while hypertensive patients (IOP above 21 mmHg) showed melatonin concentrations of 46.63 (10.28; 167.28) ng/ml (n = 14; p 
ISSN:1755-375X
1755-3768
DOI:10.1111/aos.13253