Hydropyridylation of Olefins by Intramolecular Minisci Reaction

An unprecedented cheap, mild and easy methodology for an intramolecular Minisci reaction based on a hydrogen atom transfer (HAT) initiated hydrofunctionalization of olefins was developed. The method is suitable for the construction of unusual dihydropyrano-pyridine and 1,2,3,4-tetrahydronaphthiridin...

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Bibliographic Details
Published in:Organic letters 2017-05, Vol.19 (9), p.2290-2293
Main Authors: Bordi, Samuele, Starr, Jeremy T
Format: Article
Language:English
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Summary:An unprecedented cheap, mild and easy methodology for an intramolecular Minisci reaction based on a hydrogen atom transfer (HAT) initiated hydrofunctionalization of olefins was developed. The method is suitable for the construction of unusual dihydropyrano-pyridine and 1,2,3,4-tetrahydronaphthiridine structures and, unlike most similar reactions, does not require exclusion of air from the reaction medium.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.7b00833