Can gene editing and silencing technologies play a role in the treatment of head and neck cancer?

Highlights • Gene silencing and editing technology is now routine in the laboratory. • Advanced bioinformatics of head and neck cancer is required. • Clinically useful delivery systems and target selection are critical barriers. • The PLAS, nano-patch & microneedle approaches could be potential...

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Bibliographic Details
Published in:Oral oncology 2017-05, Vol.68, p.9-19
Main Authors: Shaikh, Mushfiq H, Clarke, Daniel T.W, Johnson, Newell W, McMillan, Nigel A.J
Format: Article
Language:English
Subjects:
Carcinoma, Squamous Cell - therapy
CRISPR/Cas
Gene Editing
Gene Silencing
Head and Neck Neoplasms - therapy
Head and neck squamous cell carcinoma
Hematology, Oncology and Palliative Medicine
Human papillomavirus
Humans
Nanoparticles and lipoplex
Otolaryngology
RNA Interference
Short interfering RNA
Squamous Cell Carcinoma of Head and Neck
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Summary:Highlights • Gene silencing and editing technology is now routine in the laboratory. • Advanced bioinformatics of head and neck cancer is required. • Clinically useful delivery systems and target selection are critical barriers. • The PLAS, nano-patch & microneedle approaches could be potential delivery systems. • Targeting E6 & E7 could be an effective treatment strategy for HPV-positive HNSCC.
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2017.02.016