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Can gene editing and silencing technologies play a role in the treatment of head and neck cancer?

Highlights • Gene silencing and editing technology is now routine in the laboratory. • Advanced bioinformatics of head and neck cancer is required. • Clinically useful delivery systems and target selection are critical barriers. • The PLAS, nano-patch & microneedle approaches could be potential...

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Published in:	Oral oncology 2017-05, Vol.68, p.9-19
Main Authors:	Shaikh, Mushfiq H, Clarke, Daniel T.W, Johnson, Newell W, McMillan, Nigel A.J
Format:	Article
Language:	English
Subjects:	Carcinoma, Squamous Cell - therapy CRISPR/Cas Gene Editing Gene Silencing Head and Neck Neoplasms - therapy Head and neck squamous cell carcinoma Hematology, Oncology and Palliative Medicine Human papillomavirus Humans Nanoparticles and lipoplex Otolaryngology RNA Interference Short interfering RNA Squamous Cell Carcinoma of Head and Neck
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description	Highlights • Gene silencing and editing technology is now routine in the laboratory. • Advanced bioinformatics of head and neck cancer is required. • Clinically useful delivery systems and target selection are critical barriers. • The PLAS, nano-patch & microneedle approaches could be potential delivery systems. • Targeting E6 & E7 could be an effective treatment strategy for HPV-positive HNSCC.
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subjects	Carcinoma, Squamous Cell - therapy CRISPR/Cas Gene Editing Gene Silencing Head and Neck Neoplasms - therapy Head and neck squamous cell carcinoma Hematology, Oncology and Palliative Medicine Human papillomavirus Humans Nanoparticles and lipoplex Otolaryngology RNA Interference Short interfering RNA Squamous Cell Carcinoma of Head and Neck
title	Can gene editing and silencing technologies play a role in the treatment of head and neck cancer?
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