Micronuclei and nuclear buds: Highlighting overlooked indicators of chromosomal damage in thyroid aspiration smears

Background We aimed to examine the diagnostic utility of micronuclei (MN) and nuclear buds (NBs) in aspiration smears of the well‐differentiated epithelial lesions of thyroid. Methods One hundred five cases composed of 34 follicular nodular disease (FND), 31 Hashimoto's thyroiditis (HT), and 40...

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Bibliographic Details
Published in:Diagnostic cytopathology 2017-08, Vol.45 (8), p.673-680
Main Authors: Kokenek‐Unal, Tuba Dilay, Coban, Ipek
Format: Article
Language:English
Subjects:
Area Under Curve
Benign
Biopsy, Fine-Needle
Carcinoma, Papillary - pathology
Cell Nucleus - pathology
Chromosome aberrations
Cut-off
Diagnostic software
Evaluation
fine needle aspiration (FNA)
Hashimoto's thyroiditis
Humans
Lesions
Micronuclei
Micronuclei, Chromosome-Defective
nuclear buds
Papillary thyroid carcinoma
Retrospective Studies
ROC Curve
Thyroid
Thyroid cancer
Thyroid Cancer, Papillary
Thyroid gland
Thyroid Neoplasms - pathology
Thyroiditis
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Summary:Background We aimed to examine the diagnostic utility of micronuclei (MN) and nuclear buds (NBs) in aspiration smears of the well‐differentiated epithelial lesions of thyroid. Methods One hundred five cases composed of 34 follicular nodular disease (FND), 31 Hashimoto's thyroiditis (HT), and 40 papillary thyroid carcinoma (PTC) were compiled retrospectively. May‐ Grünwald Giemsa (MGG) stained smears of each case were selected to count cells with nuclear protrusions (NPs) per 1000 cells. The frequency of cells with NPs (MN&NBs) was compared by using Mann‐Whitney U test and Kruskal‐Wallis tests when appropriate. Post‐Hoc Tukey test was used for pairwise comparison of different diagnostic categories. By running a ROC curve analysis, diagnostic usefulness of the frequency of cells with NPs (MN&NBs) and their cut‐off values to predict malignant behavior were calculated. P 
ISSN:8755-1039
1097-0339
DOI:10.1002/dc.23738