Protective melatonin effect on oxidative stress induced by okadaic acid into rat brain

• Published in: Journal of pineal research 2003-05, Vol.34 (4), p.265-268
• Main Authors: Túnez, Isaac, Del Carmen Muñoz, M., Feijóo, Montserrat, Muñoz-Castañeda, Juan R., Bujalance, Inmaculada, Valdelvira, M. Elías, López, Pedro Montilla
• Format: Article
• Language: English
• Subjects: Animals; Biological and medical sciences; Brain - drug effects; Brain - metabolism; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Glutathione - metabolism; Glutathione Peroxidase - drug effects; Glutathione Peroxidase - metabolism; Glutathione Reductase - drug effects; Glutathione Reductase - metabolism; Glutathione Transferase - drug effects; Glutathione Transferase - metabolism; Lipid Peroxidation - drug effects; Lipid Peroxides - analysis; Lipid Peroxides - metabolism; Male; Medical sciences; melatonin; Melatonin - pharmacology; neurodegenarative disease; Neurology; Neuroprotective Agents - pharmacology; okadaic acid; Okadaic Acid - toxicity; oxidative stress; Oxidative Stress - drug effects; Rats; Rats, Wistar
• ISSN: 0742-3098; 1600-079X
• DOI: 10.1034/j.1600-079X.2003.00039.x

: We studied the effect of melatonin on the oxidative changes produced by the intracerebroventricular (i.c.v.) injection of okadaic acid (200 ng/kg BW) in the Wistar rat. The effects of okadaic acid were evaluated as changes in the quantity of lipid peroxides, reduced glutathione content (GSH) and activity of antioxidative enzymes. Okadaic acid caused lipid peroxidation (5.35 ± 0.47 μmol/g tissue in the i.c.v. vehicle group versus 10.14 ± 0.88 μmol/g tissue in the okadaic acid group, P