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Protective melatonin effect on oxidative stress induced by okadaic acid into rat brain
: We studied the effect of melatonin on the oxidative changes produced by the intracerebroventricular (i.c.v.) injection of okadaic acid (200 ng/kg BW) in the Wistar rat. The effects of okadaic acid were evaluated as changes in the quantity of lipid peroxides, reduced glutathione content (GSH) and a...
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| Published in: | Journal of pineal research 2003-05, Vol.34 (4), p.265-268 |
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| Main Authors: | , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c4639-6fe96cd7672093d6fcef1cc32fbcd2e9523afa1b3bbebabeddfaee2a0680104b3 |
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| cites | cdi_FETCH-LOGICAL-c4639-6fe96cd7672093d6fcef1cc32fbcd2e9523afa1b3bbebabeddfaee2a0680104b3 |
| container_end_page | 268 |
| container_issue | 4 |
| container_start_page | 265 |
| container_title | Journal of pineal research |
| container_volume | 34 |
| creator | Túnez, Isaac Del Carmen Muñoz, M. Feijóo, Montserrat Muñoz-Castañeda, Juan R. Bujalance, Inmaculada Valdelvira, M. Elías López, Pedro Montilla |
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We studied the effect of melatonin on the oxidative changes produced by the intracerebroventricular (i.c.v.) injection of okadaic acid (200 ng/kg BW) in the Wistar rat. The effects of okadaic acid were evaluated as changes in the quantity of lipid peroxides, reduced glutathione content (GSH) and activity of antioxidative enzymes. Okadaic acid caused lipid peroxidation (5.35 ± 0.47 μmol/g tissue in the i.c.v. vehicle group versus 10.14 ± 0.88 μmol/g tissue in the okadaic acid group, P |
| doi_str_mv | 10.1034/j.1600-079X.2003.00039.x |
| format | article |
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We studied the effect of melatonin on the oxidative changes produced by the intracerebroventricular (i.c.v.) injection of okadaic acid (200 ng/kg BW) in the Wistar rat. The effects of okadaic acid were evaluated as changes in the quantity of lipid peroxides, reduced glutathione content (GSH) and activity of antioxidative enzymes. Okadaic acid caused lipid peroxidation (5.35 ± 0.47 μmol/g tissue in the i.c.v. vehicle group versus 10.14 ± 0.88 μmol/g tissue in the okadaic acid group, P < 0.001), GSH consumption (0.115 ± 0.0065 μmol/g tissue in the i.c.v. vehicle group versus 0.024 ± 0.0021 μmol/g tissue, P < 0.001), and a reduction in the activity of GSH‐peroxidase, GSH‐reductase and GSH‐transferase between 60–80%. All these changes were prevented by pre‐injection of 4.5 mg melatonin per kg BW 2 hr before okadaic acid. These findings indicate: (i) okadaic acid induces a status of oxidative stress in the brain, characterized by a high level of lipid peroxidation, decreases in GSH content and diminished activities of antioxidative enzymes, and (ii) melatonin prevents the deleterious effects induced by okadaic acid. In conclusion, the results show the ability of melatonin to modify the neural response to okadaic acid with the protective mechanism likely involving the antioxidative processes of melatonin.</description><identifier>ISSN: 0742-3098</identifier><identifier>EISSN: 1600-079X</identifier><identifier>DOI: 10.1034/j.1600-079X.2003.00039.x</identifier><identifier>PMID: 12662348</identifier><identifier>CODEN: JPRSE9</identifier><language>eng</language><publisher>Oxford, UK: Munksgaard International Publishers</publisher><subject>Animals ; Biological and medical sciences ; Brain - drug effects ; Brain - metabolism ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Glutathione - metabolism ; Glutathione Peroxidase - drug effects ; Glutathione Peroxidase - metabolism ; Glutathione Reductase - drug effects ; Glutathione Reductase - metabolism ; Glutathione Transferase - drug effects ; Glutathione Transferase - metabolism ; Lipid Peroxidation - drug effects ; Lipid Peroxides - analysis ; Lipid Peroxides - metabolism ; Male ; Medical sciences ; melatonin ; Melatonin - pharmacology ; neurodegenarative disease ; Neurology ; Neuroprotective Agents - pharmacology ; okadaic acid ; Okadaic Acid - toxicity ; oxidative stress ; Oxidative Stress - drug effects ; Rats ; Rats, Wistar</subject><ispartof>Journal of pineal research, 2003-05, Vol.34 (4), p.265-268</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4639-6fe96cd7672093d6fcef1cc32fbcd2e9523afa1b3bbebabeddfaee2a0680104b3</citedby><cites>FETCH-LOGICAL-c4639-6fe96cd7672093d6fcef1cc32fbcd2e9523afa1b3bbebabeddfaee2a0680104b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14676843$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12662348$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Túnez, Isaac</creatorcontrib><creatorcontrib>Del Carmen Muñoz, M.</creatorcontrib><creatorcontrib>Feijóo, Montserrat</creatorcontrib><creatorcontrib>Muñoz-Castañeda, Juan R.</creatorcontrib><creatorcontrib>Bujalance, Inmaculada</creatorcontrib><creatorcontrib>Valdelvira, M. Elías</creatorcontrib><creatorcontrib>López, Pedro Montilla</creatorcontrib><title>Protective melatonin effect on oxidative stress induced by okadaic acid into rat brain</title><title>Journal of pineal research</title><addtitle>J Pineal Res</addtitle><description>:
We studied the effect of melatonin on the oxidative changes produced by the intracerebroventricular (i.c.v.) injection of okadaic acid (200 ng/kg BW) in the Wistar rat. The effects of okadaic acid were evaluated as changes in the quantity of lipid peroxides, reduced glutathione content (GSH) and activity of antioxidative enzymes. Okadaic acid caused lipid peroxidation (5.35 ± 0.47 μmol/g tissue in the i.c.v. vehicle group versus 10.14 ± 0.88 μmol/g tissue in the okadaic acid group, P < 0.001), GSH consumption (0.115 ± 0.0065 μmol/g tissue in the i.c.v. vehicle group versus 0.024 ± 0.0021 μmol/g tissue, P < 0.001), and a reduction in the activity of GSH‐peroxidase, GSH‐reductase and GSH‐transferase between 60–80%. All these changes were prevented by pre‐injection of 4.5 mg melatonin per kg BW 2 hr before okadaic acid. These findings indicate: (i) okadaic acid induces a status of oxidative stress in the brain, characterized by a high level of lipid peroxidation, decreases in GSH content and diminished activities of antioxidative enzymes, and (ii) melatonin prevents the deleterious effects induced by okadaic acid. In conclusion, the results show the ability of melatonin to modify the neural response to okadaic acid with the protective mechanism likely involving the antioxidative processes of melatonin.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Glutathione - metabolism</subject><subject>Glutathione Peroxidase - drug effects</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Glutathione Reductase - drug effects</subject><subject>Glutathione Reductase - metabolism</subject><subject>Glutathione Transferase - drug effects</subject><subject>Glutathione Transferase - metabolism</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Lipid Peroxides - analysis</subject><subject>Lipid Peroxides - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>melatonin</subject><subject>Melatonin - pharmacology</subject><subject>neurodegenarative disease</subject><subject>Neurology</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>okadaic acid</subject><subject>Okadaic Acid - toxicity</subject><subject>oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0742-3098</issn><issn>1600-079X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqNkE1vEzEQhi0EomnhLyBf4LaLvd56bYkLqmhaFCBI5UNcrLE9lpxudou9geTf4zRRe-ViWzPPO2M9hFDOas5E-3ZVc8lYxTr9s24YEzUrh663T8jsofGUzFjXNpVgWp2Q05xXBVJKyefkhDdSNqJVM_J9mcYJ3RT_IF1jD9M4xIFiCKVGx4GO2-jhvpunhDnTOPiNQ0_tjo634CE6Ci76Up9GmmCiNkEcXpBnAfqML4_3Gfl2-eHm4qpafJlfX7xfVK6VQlcyoJbOd7JrmBZeBoeBOyeaYJ1vUJ83AgJwK6xFCxa9D4DYAJOKcdZacUbeHObepfH3BvNk1jE77HsYcNxkw5XmWnS8gOoAujTmnDCYuxTXkHaGM7N3alZmr87s1Zm9U3Pv1GxL9NVxx8au0T8GjxIL8PoIQHbQhwSDi_mRa2UnVSsK9-7A_Y097v77A-bj8ro8Srw6xGOecPsQh3RrZCe6c_Pj89z8Wl6ym8Wnr2Yu_gH97KPc</recordid><startdate>200305</startdate><enddate>200305</enddate><creator>Túnez, Isaac</creator><creator>Del Carmen Muñoz, M.</creator><creator>Feijóo, Montserrat</creator><creator>Muñoz-Castañeda, Juan R.</creator><creator>Bujalance, Inmaculada</creator><creator>Valdelvira, M. Elías</creator><creator>López, Pedro Montilla</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>200305</creationdate><title>Protective melatonin effect on oxidative stress induced by okadaic acid into rat brain</title><author>Túnez, Isaac ; Del Carmen Muñoz, M. ; Feijóo, Montserrat ; Muñoz-Castañeda, Juan R. ; Bujalance, Inmaculada ; Valdelvira, M. Elías ; López, Pedro Montilla</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4639-6fe96cd7672093d6fcef1cc32fbcd2e9523afa1b3bbebabeddfaee2a0680104b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Glutathione - metabolism</topic><topic>Glutathione Peroxidase - drug effects</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Glutathione Reductase - drug effects</topic><topic>Glutathione Reductase - metabolism</topic><topic>Glutathione Transferase - drug effects</topic><topic>Glutathione Transferase - metabolism</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Lipid Peroxides - analysis</topic><topic>Lipid Peroxides - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>melatonin</topic><topic>Melatonin - pharmacology</topic><topic>neurodegenarative disease</topic><topic>Neurology</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>okadaic acid</topic><topic>Okadaic Acid - toxicity</topic><topic>oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Túnez, Isaac</creatorcontrib><creatorcontrib>Del Carmen Muñoz, M.</creatorcontrib><creatorcontrib>Feijóo, Montserrat</creatorcontrib><creatorcontrib>Muñoz-Castañeda, Juan R.</creatorcontrib><creatorcontrib>Bujalance, Inmaculada</creatorcontrib><creatorcontrib>Valdelvira, M. Elías</creatorcontrib><creatorcontrib>López, Pedro Montilla</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Journal of pineal research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Túnez, Isaac</au><au>Del Carmen Muñoz, M.</au><au>Feijóo, Montserrat</au><au>Muñoz-Castañeda, Juan R.</au><au>Bujalance, Inmaculada</au><au>Valdelvira, M. Elías</au><au>López, Pedro Montilla</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective melatonin effect on oxidative stress induced by okadaic acid into rat brain</atitle><jtitle>Journal of pineal research</jtitle><addtitle>J Pineal Res</addtitle><date>2003-05</date><risdate>2003</risdate><volume>34</volume><issue>4</issue><spage>265</spage><epage>268</epage><pages>265-268</pages><issn>0742-3098</issn><eissn>1600-079X</eissn><coden>JPRSE9</coden><abstract>:
We studied the effect of melatonin on the oxidative changes produced by the intracerebroventricular (i.c.v.) injection of okadaic acid (200 ng/kg BW) in the Wistar rat. The effects of okadaic acid were evaluated as changes in the quantity of lipid peroxides, reduced glutathione content (GSH) and activity of antioxidative enzymes. Okadaic acid caused lipid peroxidation (5.35 ± 0.47 μmol/g tissue in the i.c.v. vehicle group versus 10.14 ± 0.88 μmol/g tissue in the okadaic acid group, P < 0.001), GSH consumption (0.115 ± 0.0065 μmol/g tissue in the i.c.v. vehicle group versus 0.024 ± 0.0021 μmol/g tissue, P < 0.001), and a reduction in the activity of GSH‐peroxidase, GSH‐reductase and GSH‐transferase between 60–80%. All these changes were prevented by pre‐injection of 4.5 mg melatonin per kg BW 2 hr before okadaic acid. These findings indicate: (i) okadaic acid induces a status of oxidative stress in the brain, characterized by a high level of lipid peroxidation, decreases in GSH content and diminished activities of antioxidative enzymes, and (ii) melatonin prevents the deleterious effects induced by okadaic acid. In conclusion, the results show the ability of melatonin to modify the neural response to okadaic acid with the protective mechanism likely involving the antioxidative processes of melatonin.</abstract><cop>Oxford, UK</cop><pub>Munksgaard International Publishers</pub><pmid>12662348</pmid><doi>10.1034/j.1600-079X.2003.00039.x</doi><tpages>4</tpages></addata></record> |
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| ispartof | Journal of pineal research, 2003-05, Vol.34 (4), p.265-268 |
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| subjects | Animals Biological and medical sciences Brain - drug effects Brain - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Glutathione - metabolism Glutathione Peroxidase - drug effects Glutathione Peroxidase - metabolism Glutathione Reductase - drug effects Glutathione Reductase - metabolism Glutathione Transferase - drug effects Glutathione Transferase - metabolism Lipid Peroxidation - drug effects Lipid Peroxides - analysis Lipid Peroxides - metabolism Male Medical sciences melatonin Melatonin - pharmacology neurodegenarative disease Neurology Neuroprotective Agents - pharmacology okadaic acid Okadaic Acid - toxicity oxidative stress Oxidative Stress - drug effects Rats Rats, Wistar |
| title | Protective melatonin effect on oxidative stress induced by okadaic acid into rat brain |
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