Dynamic expression of p38β MAPK in neurons and astrocytes after transient focal ischemia

Here we report the dynamically regulated expression of p38β MAPK isoform in specific subsets of cells in postischemic brain. The activity of p38β MAPK in the postischemic brain revealed biphasic induction at 30 min and 4 days after 1 h MCAO. During the early surge period, p38β MAPK was preferentiall...

Full description

Saved in:
Bibliographic Details
Published in:Brain research 2003-06, Vol.976 (1), p.120-124
Main Authors: Piao, Chun Shu, Yu, Young-Mi, Han, Pyung-Lim, Lee, Ja-Kyeong
Format: Article
Language:English
Subjects:
Astrocyte
Biological and medical sciences
Delayed neuronal death
Focal ischemia
Medical sciences
Neurology
p38β MAPK
Vascular diseases and vascular malformations of the nervous system
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Here we report the dynamically regulated expression of p38β MAPK isoform in specific subsets of cells in postischemic brain. The activity of p38β MAPK in the postischemic brain revealed biphasic induction at 30 min and 4 days after 1 h MCAO. During the early surge period, p38β MAPK was preferentially localized in the nucleus and dendrites of neurons in the future infarction area, while during the delayed surge p38β MAPK was heavily induced in reactive astrocytes in penumbra. The temporally and spatially regulated pattern of p38β MAPK expression in the postischemic brain suggests distinct roles of p38β MAPK in neuronal death and in the astrocyte activation.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(03)02579-4