Meta-analytic investigations of common and distinct grey matter alterations in youths and adults with obsessive-compulsive disorder

•The most robust GM changes of OCD patients are in the prefrontal-striatal circuit.•Different GM alterations in OCD-youths and OCD-adults are identified.•The medication effects may be more pronounced in the putamen in OCD-adults. Obsessive-compulsive disorder (OCD) is a disabling illness with onset...

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Published in:Neuroscience and biobehavioral reviews 2017-07, Vol.78, p.91-103
Main Authors: Hu, Xinyu, Du, Mingying, Chen, Lizhou, Li, Lei, Zhou, Ming, Zhang, Lianqing, Liu, Qi, Lu, Lu, Mreedha, Kunal, Huang, Xiaoqi, Gong, Qiyong
Format: Article
Language:English
Subjects:
Adolescent
Adult
Brain
Humans
Magnetic Resonance Imaging
Meta-analysis
Obsessive-Compulsive Disorder
Signed differential mapping
Structural neuroimaging
Voxel based morphometry
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Summary:•The most robust GM changes of OCD patients are in the prefrontal-striatal circuit.•Different GM alterations in OCD-youths and OCD-adults are identified.•The medication effects may be more pronounced in the putamen in OCD-adults. Obsessive-compulsive disorder (OCD) is a disabling illness with onset generally in childhood. OCD-youths differ from OCD-adults with regard to gender distribution, comorbidity patterns and treatment options. However, little is known about the neural correlate differences underpin those two populations. The current meta-analysis summarizes voxel based morphometry findings to elucidate whether differences of neural correlates exist between these two populations. Both OCD-youths and OCD-adults demonstrated greater striatal volume and smaller prefrontal grey matter volume (GMV). However, smaller GMV in left visual cortex was observed in OCD-youths only, while smaller GMV in anterior cingulate gyrus and greater GMV in cerebellum were demonstrated only in OCD-adults. Meta-regression showed greater GMV in left putamen was most prominent in samples with higher percentages of medicated OCD-adults. Our findings confirmed the most consistent GMV alterations in OCD were in prefrontal-striatal circuitry. Besides, other regions may involve at different developmental stages including deficits of visual cortex in OCD-youths and abnormalities of limbic-cerebellar circuit in OCD-adults. Medication effect may be more pronounced in the striatum, especially the putamen.
ISSN:0149-7634
1873-7528
DOI:10.1016/j.neubiorev.2017.04.012