Meta-analysis of hypertension and osteoporotic fracture risk in women and men

Summary The present meta-analysis synthesized evidence from 10 articles encompassing 28 independent studies to verify the association between hypertension and osteoporotic fracture risk in women and men. Our results indicate that the risk of osteoporotic fracture among individuals with hypertension...

Full description

Saved in:
Bibliographic Details
Published in:Osteoporosis international 2017-08, Vol.28 (8), p.2309-2318
Main Authors: Li, C., Zeng, Y., Tao, L., Liu, S., Ni, Z., Huang, Q., Wang, Q.
Format: Article
Language:English
Subjects:
Breasts
Endocrinology
Epidemiology
Female
Fractures
Humans
Hypertension
Hypertension - complications
Hypertension - epidemiology
Independent study
Male
Medicine
Medicine & Public Health
Meta-analysis
Original Article
Orthopedics
Osteoporosis
Osteoporotic Fractures - epidemiology
Osteoporotic Fractures - etiology
Publication Bias
Rheumatology
Risk Assessment - methods
Studies
Surgeons General
Systematic review
Women
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary The present meta-analysis synthesized evidence from 10 articles encompassing 28 independent studies to verify the association between hypertension and osteoporotic fracture risk in women and men. Our results indicate that the risk of osteoporotic fracture among individuals with hypertension was higher than that among individuals without hypertension. Introduction Epidemiological studies have suggested that hypertension is related to osteoporotic fracture. However, discrepancies exist in the reported findings. In this study, a systematic review of relevant published articles was conducted to verify the association between hypertension and osteoporotic fracture risk in women and men. Methods PubMed (1953_October 5th, 2016) and Embase (1974_October 5th, 2016) were systematically searched for relevant articles. Odds ratios (ORs) and confidence intervals (CIs) were derived using random effect models. Categorical, subgroup, heterogeneity, publication bias, and meta-regression analyses were conducted. Results We analyzed 10 articles encompassing 28 independent studies, 1,430,431 participants, and 148,048 osteoporotic fracture cases. The risk of osteoporotic fracture among individuals with hypertension was higher (pooled OR = 1.33, 95% CI 1.25–1.40; I 2  = 72.3%, P  
ISSN:0937-941X
1433-2965
DOI:10.1007/s00198-017-4050-z