Effect of Intensive Periodontal Therapy on Blood Pressure and Endothelial Microparticles in Patients With Prehypertension and Periodontitis: A Randomized Controlled Trial

Background: Although some studies show a positive association between periodontitis and blood pressure (BP) elevation, research on the effect of intensive periodontal treatment on decline in BP levels and endothelial microparticles (EMPs) without any antihypertensive management is lacking. Therefore...

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Published in:Journal of periodontology (1970) 2017-08, Vol.88 (8), p.711-722
Main Authors: Zhou, Qian‐Bing, Xia, Wen‐Hao, Ren, Jing, Yu, Bing‐Bo, Tong, Xin‐Zhu, Chen, Yan‐Bin, Chen, Shan, Feng, Lei, Dai, Jing, Tao, Jun, Yang, Jun‐Ying
Format: Article
Language:English
Subjects:
Adult
Biomarkers - metabolism
Cardiovascular diseases
Cell-Derived Microparticles - metabolism
clinical trials as topic
Dentistry
Endothelium, Vascular - metabolism
Enzyme-Linked Immunosorbent Assay
Female
Humans
Male
periodontitis
Periodontitis - therapy
Prehypertension - prevention & control
Reproducibility of Results
Surveys and Questionnaires
Treatment Outcome
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Summary:Background: Although some studies show a positive association between periodontitis and blood pressure (BP) elevation, research on the effect of intensive periodontal treatment on decline in BP levels and endothelial microparticles (EMPs) without any antihypertensive management is lacking. Therefore, the present clinical trial explores whether intensive periodontal therapy would lower BP levels and EMPs of patients with prehypertension with periodontitis. Methods: From a total 107 patients, 95 underwent randomization (47 assigned to control‐treatment [CT] group and 48 assigned to intensive‐treatment [IT] group) and completed the trial. Patients received intervention for 4 consecutive weeks and were followed for 6 months. Levels of BP and EMPs were evaluated at baseline and 1, 3, and 6 months after intervention. Results: Periodontal conditions were significantly improved (P
ISSN:0022-3492
1943-3670
DOI:10.1902/jop.2017.160447