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Effect of Intensive Periodontal Therapy on Blood Pressure and Endothelial Microparticles in Patients With Prehypertension and Periodontitis: A Randomized Controlled Trial
Background: Although some studies show a positive association between periodontitis and blood pressure (BP) elevation, research on the effect of intensive periodontal treatment on decline in BP levels and endothelial microparticles (EMPs) without any antihypertensive management is lacking. Therefore...
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| Published in: | Journal of periodontology (1970) 2017-08, Vol.88 (8), p.711-722 |
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| Main Authors: | , , , , , , , , , , |
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| container_end_page | 722 |
| container_issue | 8 |
| container_start_page | 711 |
| container_title | Journal of periodontology (1970) |
| container_volume | 88 |
| creator | Zhou, Qian‐Bing Xia, Wen‐Hao Ren, Jing Yu, Bing‐Bo Tong, Xin‐Zhu Chen, Yan‐Bin Chen, Shan Feng, Lei Dai, Jing Tao, Jun Yang, Jun‐Ying |
| description | Background: Although some studies show a positive association between periodontitis and blood pressure (BP) elevation, research on the effect of intensive periodontal treatment on decline in BP levels and endothelial microparticles (EMPs) without any antihypertensive management is lacking. Therefore, the present clinical trial explores whether intensive periodontal therapy would lower BP levels and EMPs of patients with prehypertension with periodontitis.
Methods: From a total 107 patients, 95 underwent randomization (47 assigned to control‐treatment [CT] group and 48 assigned to intensive‐treatment [IT] group) and completed the trial. Patients received intervention for 4 consecutive weeks and were followed for 6 months. Levels of BP and EMPs were evaluated at baseline and 1, 3, and 6 months after intervention.
Results: Periodontal conditions were significantly improved (P |
| doi_str_mv | 10.1902/jop.2017.160447 |
| format | article |
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Methods: From a total 107 patients, 95 underwent randomization (47 assigned to control‐treatment [CT] group and 48 assigned to intensive‐treatment [IT] group) and completed the trial. Patients received intervention for 4 consecutive weeks and were followed for 6 months. Levels of BP and EMPs were evaluated at baseline and 1, 3, and 6 months after intervention.
Results: Periodontal conditions were significantly improved (P <0.05) 6 months after intensive periodontal treatment. In parallel, the primary outcomes including systolic and diastolic BP and EMPs were markedly reduced in the IT group compared with the CT group (absolute difference: 12.57 and 9.65 mm Hg and 581.59/μL, respectively; 95% confidence intervals: 10.45 to 14.69, 7.06 to 12.24, and 348.12 to 815.06, respectively; P <0.05). Reduction in BP levels and EMPs was related to improvement in probing depth (r = 0.358, 0.363, and 0.676, respectively, by the Pearson product‐moment correlation; P = 0.009, 0.008, and P <0.001, respectively).
Conclusion: To the best knowledge of the authors, the present study demonstrates for the first time that intensive periodontal intervention without any antihypertensive medication therapy may be an effective means to lower levels of BP and EMPs in patients with prehypertension with periodontitis.</description><identifier>ISSN: 0022-3492</identifier><identifier>EISSN: 1943-3670</identifier><identifier>DOI: 10.1902/jop.2017.160447</identifier><identifier>PMID: 28452620</identifier><language>eng</language><publisher>United States: American Academy of Periodontology</publisher><subject>Adult ; Biomarkers - metabolism ; Cardiovascular diseases ; Cell-Derived Microparticles - metabolism ; clinical trials as topic ; Dentistry ; Endothelium, Vascular - metabolism ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Male ; periodontitis ; Periodontitis - therapy ; Prehypertension - prevention & control ; Reproducibility of Results ; Surveys and Questionnaires ; Treatment Outcome</subject><ispartof>Journal of periodontology (1970), 2017-08, Vol.88 (8), p.711-722</ispartof><rights>2017 American Academy of Periodontology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3431-5bc8d2a0bffa1b621787e34f0feb84a20407b69274be3cdec507949a60c89a413</citedby><cites>FETCH-LOGICAL-c3431-5bc8d2a0bffa1b621787e34f0feb84a20407b69274be3cdec507949a60c89a413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28452620$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Qian‐Bing</creatorcontrib><creatorcontrib>Xia, Wen‐Hao</creatorcontrib><creatorcontrib>Ren, Jing</creatorcontrib><creatorcontrib>Yu, Bing‐Bo</creatorcontrib><creatorcontrib>Tong, Xin‐Zhu</creatorcontrib><creatorcontrib>Chen, Yan‐Bin</creatorcontrib><creatorcontrib>Chen, Shan</creatorcontrib><creatorcontrib>Feng, Lei</creatorcontrib><creatorcontrib>Dai, Jing</creatorcontrib><creatorcontrib>Tao, Jun</creatorcontrib><creatorcontrib>Yang, Jun‐Ying</creatorcontrib><title>Effect of Intensive Periodontal Therapy on Blood Pressure and Endothelial Microparticles in Patients With Prehypertension and Periodontitis: A Randomized Controlled Trial</title><title>Journal of periodontology (1970)</title><addtitle>J Periodontol</addtitle><description>Background: Although some studies show a positive association between periodontitis and blood pressure (BP) elevation, research on the effect of intensive periodontal treatment on decline in BP levels and endothelial microparticles (EMPs) without any antihypertensive management is lacking. Therefore, the present clinical trial explores whether intensive periodontal therapy would lower BP levels and EMPs of patients with prehypertension with periodontitis.
Methods: From a total 107 patients, 95 underwent randomization (47 assigned to control‐treatment [CT] group and 48 assigned to intensive‐treatment [IT] group) and completed the trial. Patients received intervention for 4 consecutive weeks and were followed for 6 months. Levels of BP and EMPs were evaluated at baseline and 1, 3, and 6 months after intervention.
Results: Periodontal conditions were significantly improved (P <0.05) 6 months after intensive periodontal treatment. In parallel, the primary outcomes including systolic and diastolic BP and EMPs were markedly reduced in the IT group compared with the CT group (absolute difference: 12.57 and 9.65 mm Hg and 581.59/μL, respectively; 95% confidence intervals: 10.45 to 14.69, 7.06 to 12.24, and 348.12 to 815.06, respectively; P <0.05). Reduction in BP levels and EMPs was related to improvement in probing depth (r = 0.358, 0.363, and 0.676, respectively, by the Pearson product‐moment correlation; P = 0.009, 0.008, and P <0.001, respectively).
Conclusion: To the best knowledge of the authors, the present study demonstrates for the first time that intensive periodontal intervention without any antihypertensive medication therapy may be an effective means to lower levels of BP and EMPs in patients with prehypertension with periodontitis.</description><subject>Adult</subject><subject>Biomarkers - metabolism</subject><subject>Cardiovascular diseases</subject><subject>Cell-Derived Microparticles - metabolism</subject><subject>clinical trials as topic</subject><subject>Dentistry</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>periodontitis</subject><subject>Periodontitis - therapy</subject><subject>Prehypertension - prevention & control</subject><subject>Reproducibility of Results</subject><subject>Surveys and Questionnaires</subject><subject>Treatment Outcome</subject><issn>0022-3492</issn><issn>1943-3670</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqFkU9vEzEQxS0EoqFw5oZ85LLp-M-u19xKFGhRq0ZVEMeVd3dWceWsF9spSj9SP2UdUnrlNJ7R770n6xHykcGcaeBnd36ac2BqziqQUr0iM6alKESl4DWZAXBeCKn5CXkX411emRTwlpzwWpa84jAjj8thwC5RP9DLMeEY7T3SFQbrez8m4-h6g8FMe-pH-tV539NVwBh3AakZe7oce5826Gwmr20X_GRCsp3DSO1IVyZZHFOkv2zaHISb_YThb0q2O-hfkmyy8Qs9p7f56rf2AXu6yOfgncvPdcgB78mbwbiIH57nKfn5bbleXBRXN98vF-dXRSekYEXZdnXPDbTDYFhbcaZqhUIOMGBbS8NBgmorzZVsUXQ9diUoLbWpoKu1kUycks9H3yn43zuMqdna2KFzZkS_iw2rtShlXYHO6NkRzT-PMeDQTMFuTdg3DJpDQU0uqDkU1BwLyopPz-a7dov9C_-vkQyUR-CPdbj_n1_zY7W8BcWYeAKR1aAQ</recordid><startdate>201708</startdate><enddate>201708</enddate><creator>Zhou, Qian‐Bing</creator><creator>Xia, Wen‐Hao</creator><creator>Ren, Jing</creator><creator>Yu, Bing‐Bo</creator><creator>Tong, Xin‐Zhu</creator><creator>Chen, Yan‐Bin</creator><creator>Chen, Shan</creator><creator>Feng, Lei</creator><creator>Dai, Jing</creator><creator>Tao, Jun</creator><creator>Yang, Jun‐Ying</creator><general>American Academy of Periodontology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201708</creationdate><title>Effect of Intensive Periodontal Therapy on Blood Pressure and Endothelial Microparticles in Patients With Prehypertension and Periodontitis: A Randomized Controlled Trial</title><author>Zhou, Qian‐Bing ; Xia, Wen‐Hao ; Ren, Jing ; Yu, Bing‐Bo ; Tong, Xin‐Zhu ; Chen, Yan‐Bin ; Chen, Shan ; Feng, Lei ; Dai, Jing ; Tao, Jun ; Yang, Jun‐Ying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3431-5bc8d2a0bffa1b621787e34f0feb84a20407b69274be3cdec507949a60c89a413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Biomarkers - metabolism</topic><topic>Cardiovascular diseases</topic><topic>Cell-Derived Microparticles - metabolism</topic><topic>clinical trials as topic</topic><topic>Dentistry</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>periodontitis</topic><topic>Periodontitis - therapy</topic><topic>Prehypertension - prevention & control</topic><topic>Reproducibility of Results</topic><topic>Surveys and Questionnaires</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Qian‐Bing</creatorcontrib><creatorcontrib>Xia, Wen‐Hao</creatorcontrib><creatorcontrib>Ren, Jing</creatorcontrib><creatorcontrib>Yu, Bing‐Bo</creatorcontrib><creatorcontrib>Tong, Xin‐Zhu</creatorcontrib><creatorcontrib>Chen, Yan‐Bin</creatorcontrib><creatorcontrib>Chen, Shan</creatorcontrib><creatorcontrib>Feng, Lei</creatorcontrib><creatorcontrib>Dai, Jing</creatorcontrib><creatorcontrib>Tao, Jun</creatorcontrib><creatorcontrib>Yang, Jun‐Ying</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of periodontology (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Qian‐Bing</au><au>Xia, Wen‐Hao</au><au>Ren, Jing</au><au>Yu, Bing‐Bo</au><au>Tong, Xin‐Zhu</au><au>Chen, Yan‐Bin</au><au>Chen, Shan</au><au>Feng, Lei</au><au>Dai, Jing</au><au>Tao, Jun</au><au>Yang, Jun‐Ying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Intensive Periodontal Therapy on Blood Pressure and Endothelial Microparticles in Patients With Prehypertension and Periodontitis: A Randomized Controlled Trial</atitle><jtitle>Journal of periodontology (1970)</jtitle><addtitle>J Periodontol</addtitle><date>2017-08</date><risdate>2017</risdate><volume>88</volume><issue>8</issue><spage>711</spage><epage>722</epage><pages>711-722</pages><issn>0022-3492</issn><eissn>1943-3670</eissn><abstract>Background: Although some studies show a positive association between periodontitis and blood pressure (BP) elevation, research on the effect of intensive periodontal treatment on decline in BP levels and endothelial microparticles (EMPs) without any antihypertensive management is lacking. Therefore, the present clinical trial explores whether intensive periodontal therapy would lower BP levels and EMPs of patients with prehypertension with periodontitis.
Methods: From a total 107 patients, 95 underwent randomization (47 assigned to control‐treatment [CT] group and 48 assigned to intensive‐treatment [IT] group) and completed the trial. Patients received intervention for 4 consecutive weeks and were followed for 6 months. Levels of BP and EMPs were evaluated at baseline and 1, 3, and 6 months after intervention.
Results: Periodontal conditions were significantly improved (P <0.05) 6 months after intensive periodontal treatment. In parallel, the primary outcomes including systolic and diastolic BP and EMPs were markedly reduced in the IT group compared with the CT group (absolute difference: 12.57 and 9.65 mm Hg and 581.59/μL, respectively; 95% confidence intervals: 10.45 to 14.69, 7.06 to 12.24, and 348.12 to 815.06, respectively; P <0.05). Reduction in BP levels and EMPs was related to improvement in probing depth (r = 0.358, 0.363, and 0.676, respectively, by the Pearson product‐moment correlation; P = 0.009, 0.008, and P <0.001, respectively).
Conclusion: To the best knowledge of the authors, the present study demonstrates for the first time that intensive periodontal intervention without any antihypertensive medication therapy may be an effective means to lower levels of BP and EMPs in patients with prehypertension with periodontitis.</abstract><cop>United States</cop><pub>American Academy of Periodontology</pub><pmid>28452620</pmid><doi>10.1902/jop.2017.160447</doi><tpages>12</tpages></addata></record> |
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| identifier | ISSN: 0022-3492 |
| ispartof | Journal of periodontology (1970), 2017-08, Vol.88 (8), p.711-722 |
| issn | 0022-3492 1943-3670 |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adult Biomarkers - metabolism Cardiovascular diseases Cell-Derived Microparticles - metabolism clinical trials as topic Dentistry Endothelium, Vascular - metabolism Enzyme-Linked Immunosorbent Assay Female Humans Male periodontitis Periodontitis - therapy Prehypertension - prevention & control Reproducibility of Results Surveys and Questionnaires Treatment Outcome |
| title | Effect of Intensive Periodontal Therapy on Blood Pressure and Endothelial Microparticles in Patients With Prehypertension and Periodontitis: A Randomized Controlled Trial |
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