Protective and pathogenic memory plasma cells

Highlights • Plasma cells can be short-lived plasmablast or long-lived memory plasma cells • Memory plasma cells provide persisting antibody titers for years, even decades • Protective memory plasma cells are important for longlasting immunity to infections • Pathogenic autoreactive memory plasma ce...

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Bibliographic Details
Published in:Immunology letters 2017-09, Vol.189, p.10-12
Main Authors: Hoyer, Bimba F, Radbruch, Andreas
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antibodies - metabolism
Autoimmunity
B-Lymphocytes - immunology
Humans
Immunity, Humoral
Immunoglobulin Class Switching
Immunologic Memory
Infection - immunology
Memory
Plasma cells
Plasma Cells - immunology
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Summary:Highlights • Plasma cells can be short-lived plasmablast or long-lived memory plasma cells • Memory plasma cells provide persisting antibody titers for years, even decades • Protective memory plasma cells are important for longlasting immunity to infections • Pathogenic autoreactive memory plasma cells exist in autoimmunity • They are refractory to conventional immunosuppression and their depletion constitutes a therapeutic challenge
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2017.04.014