Protective and pathogenic memory plasma cells

Highlights • Plasma cells can be short-lived plasmablast or long-lived memory plasma cells • Memory plasma cells provide persisting antibody titers for years, even decades • Protective memory plasma cells are important for longlasting immunity to infections • Pathogenic autoreactive memory plasma ce...

Full description

Saved in:
Bibliographic Details
Published in:Immunology letters 2017-09, Vol.189, p.10-12
Main Authors: Hoyer, Bimba F, Radbruch, Andreas
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antibodies - metabolism
Autoimmunity
B-Lymphocytes - immunology
Humans
Immunity, Humoral
Immunoglobulin Class Switching
Immunologic Memory
Infection - immunology
Memory
Plasma cells
Plasma Cells - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c480t-5551181b524b373b9a4345e16d9f32c09f0f03c485c3b099326418f3930742193
cites cdi_FETCH-LOGICAL-c480t-5551181b524b373b9a4345e16d9f32c09f0f03c485c3b099326418f3930742193
container_end_page 12
container_issue
container_start_page 10
container_title Immunology letters
container_volume 189
creator Hoyer, Bimba F
Radbruch, Andreas
description Highlights • Plasma cells can be short-lived plasmablast or long-lived memory plasma cells • Memory plasma cells provide persisting antibody titers for years, even decades • Protective memory plasma cells are important for longlasting immunity to infections • Pathogenic autoreactive memory plasma cells exist in autoimmunity • They are refractory to conventional immunosuppression and their depletion constitutes a therapeutic challenge
doi_str_mv 10.1016/j.imlet.2017.04.014
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1893549573</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0165247817301128</els_id><sourcerecordid>1893549573</sourcerecordid><originalsourceid>FETCH-LOGICAL-c480t-5551181b524b373b9a4345e16d9f32c09f0f03c485c3b099326418f3930742193</originalsourceid><addsrcrecordid>eNqFkU1v1DAQhi0EarelvwAJ5cglYcZjb-IDSKgCilQJJOBsOc4EvORjsbOV9t_jsIVDLz3N5Xnn4xkhXiBUCLh9vavCOPBSScC6AlUBqidig01tStBKPhWbTOlSqro5Fxcp7QBQk6IzcS4bpTVu640ov8R5Yb-EOy7c1BV7t_ycf_AUfDHyOMdjsR9cGl3heRjSc_Gsd0Piq_t6Kb5_eP_t-qa8_fzx0_W729KrBpZS5-bYYKulaqmm1jhFSjNuO9OT9GB66IEyqz21YAzJrcKmJ0NQK4mGLsWrU999nH8fOC12DGndwE08H5LFxpBWRteUUTqhPs4pRe7tPobRxaNFsKsnu7N_PdnVkwVls6ecenk_4NCO3P3P_BOTgTcngPOZd4GjTT7w5LkLMeuy3RweGfD2Qd4PIVt1wy8-ctrNhzhlgxZtkhbs1_VV66ewJkCUDf0Bws2MCg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1893549573</pqid></control><display><type>article</type><title>Protective and pathogenic memory plasma cells</title><source>ScienceDirect Freedom Collection</source><creator>Hoyer, Bimba F ; Radbruch, Andreas</creator><creatorcontrib>Hoyer, Bimba F ; Radbruch, Andreas</creatorcontrib><description>Highlights • Plasma cells can be short-lived plasmablast or long-lived memory plasma cells • Memory plasma cells provide persisting antibody titers for years, even decades • Protective memory plasma cells are important for longlasting immunity to infections • Pathogenic autoreactive memory plasma cells exist in autoimmunity • They are refractory to conventional immunosuppression and their depletion constitutes a therapeutic challenge</description><identifier>ISSN: 0165-2478</identifier><identifier>EISSN: 1879-0542</identifier><identifier>DOI: 10.1016/j.imlet.2017.04.014</identifier><identifier>PMID: 28455167</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Allergy and Immunology ; Animals ; Antibodies - metabolism ; Autoimmunity ; B-Lymphocytes - immunology ; Humans ; Immunity, Humoral ; Immunoglobulin Class Switching ; Immunologic Memory ; Infection - immunology ; Memory ; Plasma cells ; Plasma Cells - immunology</subject><ispartof>Immunology letters, 2017-09, Vol.189, p.10-12</ispartof><rights>2017</rights><rights>Copyright © 2017. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-5551181b524b373b9a4345e16d9f32c09f0f03c485c3b099326418f3930742193</citedby><cites>FETCH-LOGICAL-c480t-5551181b524b373b9a4345e16d9f32c09f0f03c485c3b099326418f3930742193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28455167$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoyer, Bimba F</creatorcontrib><creatorcontrib>Radbruch, Andreas</creatorcontrib><title>Protective and pathogenic memory plasma cells</title><title>Immunology letters</title><addtitle>Immunol Lett</addtitle><description>Highlights • Plasma cells can be short-lived plasmablast or long-lived memory plasma cells • Memory plasma cells provide persisting antibody titers for years, even decades • Protective memory plasma cells are important for longlasting immunity to infections • Pathogenic autoreactive memory plasma cells exist in autoimmunity • They are refractory to conventional immunosuppression and their depletion constitutes a therapeutic challenge</description><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Antibodies - metabolism</subject><subject>Autoimmunity</subject><subject>B-Lymphocytes - immunology</subject><subject>Humans</subject><subject>Immunity, Humoral</subject><subject>Immunoglobulin Class Switching</subject><subject>Immunologic Memory</subject><subject>Infection - immunology</subject><subject>Memory</subject><subject>Plasma cells</subject><subject>Plasma Cells - immunology</subject><issn>0165-2478</issn><issn>1879-0542</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqFkU1v1DAQhi0EarelvwAJ5cglYcZjb-IDSKgCilQJJOBsOc4EvORjsbOV9t_jsIVDLz3N5Xnn4xkhXiBUCLh9vavCOPBSScC6AlUBqidig01tStBKPhWbTOlSqro5Fxcp7QBQk6IzcS4bpTVu640ov8R5Yb-EOy7c1BV7t_ycf_AUfDHyOMdjsR9cGl3heRjSc_Gsd0Piq_t6Kb5_eP_t-qa8_fzx0_W729KrBpZS5-bYYKulaqmm1jhFSjNuO9OT9GB66IEyqz21YAzJrcKmJ0NQK4mGLsWrU999nH8fOC12DGndwE08H5LFxpBWRteUUTqhPs4pRe7tPobRxaNFsKsnu7N_PdnVkwVls6ecenk_4NCO3P3P_BOTgTcngPOZd4GjTT7w5LkLMeuy3RweGfD2Qd4PIVt1wy8-ctrNhzhlgxZtkhbs1_VV66ewJkCUDf0Bws2MCg</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Hoyer, Bimba F</creator><creator>Radbruch, Andreas</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170901</creationdate><title>Protective and pathogenic memory plasma cells</title><author>Hoyer, Bimba F ; Radbruch, Andreas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-5551181b524b373b9a4345e16d9f32c09f0f03c485c3b099326418f3930742193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Antibodies - metabolism</topic><topic>Autoimmunity</topic><topic>B-Lymphocytes - immunology</topic><topic>Humans</topic><topic>Immunity, Humoral</topic><topic>Immunoglobulin Class Switching</topic><topic>Immunologic Memory</topic><topic>Infection - immunology</topic><topic>Memory</topic><topic>Plasma cells</topic><topic>Plasma Cells - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoyer, Bimba F</creatorcontrib><creatorcontrib>Radbruch, Andreas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Immunology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoyer, Bimba F</au><au>Radbruch, Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective and pathogenic memory plasma cells</atitle><jtitle>Immunology letters</jtitle><addtitle>Immunol Lett</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>189</volume><spage>10</spage><epage>12</epage><pages>10-12</pages><issn>0165-2478</issn><eissn>1879-0542</eissn><abstract>Highlights • Plasma cells can be short-lived plasmablast or long-lived memory plasma cells • Memory plasma cells provide persisting antibody titers for years, even decades • Protective memory plasma cells are important for longlasting immunity to infections • Pathogenic autoreactive memory plasma cells exist in autoimmunity • They are refractory to conventional immunosuppression and their depletion constitutes a therapeutic challenge</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28455167</pmid><doi>10.1016/j.imlet.2017.04.014</doi><tpages>3</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0165-2478
ispartof Immunology letters, 2017-09, Vol.189, p.10-12
issn 0165-2478
1879-0542
language eng
recordid cdi_proquest_miscellaneous_1893549573
source ScienceDirect Freedom Collection
subjects Allergy and Immunology
Animals
Antibodies - metabolism
Autoimmunity
B-Lymphocytes - immunology
Humans
Immunity, Humoral
Immunoglobulin Class Switching
Immunologic Memory
Infection - immunology
Memory
Plasma cells
Plasma Cells - immunology
title Protective and pathogenic memory plasma cells
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T13%3A51%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Protective%20and%20pathogenic%20memory%20plasma%20cells&rft.jtitle=Immunology%20letters&rft.au=Hoyer,%20Bimba%20F&rft.date=2017-09-01&rft.volume=189&rft.spage=10&rft.epage=12&rft.pages=10-12&rft.issn=0165-2478&rft.eissn=1879-0542&rft_id=info:doi/10.1016/j.imlet.2017.04.014&rft_dat=%3Cproquest_cross%3E1893549573%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c480t-5551181b524b373b9a4345e16d9f32c09f0f03c485c3b099326418f3930742193%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1893549573&rft_id=info:pmid/28455167&rfr_iscdi=true