Effect of Ticagrelor Versus Clopidogrel on Vascular Reactivity
Inclusion criteria included age >18 years, coronary artery disease, and ≥2 cardiovascular risk factors. Exclusion criteria included heart block, bleeding, stroke, dyspnea, oral anticoagulants, valvular heart disease, treatment with strong cytochrome P450 isoenzyme CYP3A4 inhibitors, drug or alcoh...
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Published in: | Journal of the American College of Cardiology 2017-05, Vol.69 (17), p.2246-2248 |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Inclusion criteria included age >18 years, coronary artery disease, and ≥2 cardiovascular risk factors. Exclusion criteria included heart block, bleeding, stroke, dyspnea, oral anticoagulants, valvular heart disease, treatment with strong cytochrome P450 isoenzyme CYP3A4 inhibitors, drug or alcohol abuse, severe liver disease, hypersensitivity to the study drugs, pregnancy, and latex allergy. Clopidogrel also has been shown to increase nitric oxide bioavailability, a finding that may explain the observed positive effects of clopidogrel on vascular reactivity. |
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ISSN: | 0735-1097 1558-3597 |
DOI: | 10.1016/j.jacc.2017.02.048 |