Effect of Ticagrelor Versus Clopidogrel on Vascular Reactivity

Inclusion criteria included age >18 years, coronary artery disease, and ≥2 cardiovascular risk factors. Exclusion criteria included heart block, bleeding, stroke, dyspnea, oral anticoagulants, valvular heart disease, treatment with strong cytochrome P450 isoenzyme CYP3A4 inhibitors, drug or alcoh...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American College of Cardiology 2017-05, Vol.69 (17), p.2246-2248
Main Authors: Alemayehu, Mistre, MSc, Kim, Richard B., MD, Lavi, Ronit, MD, Gong, Inna, PhD, D’Alfonso, Sabrina, MSc, Mansell, Sara E., BSc, Wall, Sabrina, BSc, Lavi, Shahar, MD
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Inclusion criteria included age >18 years, coronary artery disease, and ≥2 cardiovascular risk factors. Exclusion criteria included heart block, bleeding, stroke, dyspnea, oral anticoagulants, valvular heart disease, treatment with strong cytochrome P450 isoenzyme CYP3A4 inhibitors, drug or alcohol abuse, severe liver disease, hypersensitivity to the study drugs, pregnancy, and latex allergy. Clopidogrel also has been shown to increase nitric oxide bioavailability, a finding that may explain the observed positive effects of clopidogrel on vascular reactivity.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2017.02.048