Do the accelerating actions of tianeptine and l-arginine on cortical spreading depression interact? An electrophysiological analysis in young and adult rats

•We studied tianeptine/arginine interaction on cortical spreading depression (CSD).•Systemic neonatal treatment of rats with arginine accelerated CSD in adult life.•Topical application of tianeptine reversibly increased CSD propagation velocity.•Combination of both treatments did not further enhance...

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Bibliographic Details
Published in:Neuroscience letters 2017-05, Vol.650, p.134-138
Main Authors: Maia, Luciana Maria Silva de Seixas, Amancio-dos-Santos, Angela, Germano, Paula Catirina Pereira da Silva, Falcão, Anna Carolina Santos Marinho, Duda-de-Oliveira, Desirré, Guedes, Rubem Carlos Araújo
Format: Article
Language:English
Subjects:
Aging - physiology
Animals
Arginine - administration & dosage
Brain - drug effects
Brain - physiology
Brain Mapping
Cortical spreading depression
Cortical Spreading Depression - drug effects
Cortical Spreading Depression - physiology
Dose-Response Relationship, Drug
Drug Combinations
Female
l-arginine
Nitric oxide
Rats
Rats, Wistar
Serotonin
Thiazepines - administration & dosage
Tianeptine
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Summary:•We studied tianeptine/arginine interaction on cortical spreading depression (CSD).•Systemic neonatal treatment of rats with arginine accelerated CSD in adult life.•Topical application of tianeptine reversibly increased CSD propagation velocity.•Combination of both treatments did not further enhance CSD.•We suggest that arginine and tianeptine probably act on CSD via separate mechanisms. In the rat, we previously demonstrated that serotonin-enhancing drugs impair cortical spreading depression (CSD) and that l-arginine (arginine) treatment enhances CSD. Here, we investigated the interaction between topical application of the serotonin uptake enhancer tianeptine and systemic arginine administration on CSD. From postnatal day 7–28, female Wistar rats (n=40) received by gavage 300mg/Kg/day arginine (n=20) or water (n=20). Half of the arginine- or water-treated rats underwent CSD recording at 30–40days of age (young), while the other half was recorded at 90–120days (adult). Following baseline recording (four episodes of CSD), we applied tianeptine solution (10mg/ml) to a rectangular portion of the intact dura mater for 10-min and then elicited CSD. This procedure was repeated three times. Compared to baseline values, CSD velocities and amplitudes following tianeptine application increased, and CSD duration decreased significantly (p
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2017.04.044