IL-33 improves the suppressive potential of regulatory T cells in patients with type 1 diabetes

Highlights • We analyzed the influence of IL-33 on Treg function In type 1 diabetes. • We analyzed the ability of IL-33 treated Tregs to inhibit the production of IFN-γ by effector lymphocytes in mixed cocultures. • IL-33 treatment of Tregs derived from patients with type 1 diabetes resulted in quan...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2017-06, Vol.128, p.67-73
Main Authors: RYBA-STANISŁAWOWSKA, Monika, BUKSA, Laura, BRANDT, Agnieszka, JUHAS, Ulana, MYŚLIWIEC, Małgorzata
Format: Article
Language:English
Subjects:
Adolescent
Diabetes Mellitus, Type 1 - metabolism
Diabetes type 1
Endocrinology & Metabolism
Female
Humans
IL-33
Interleukin-33 - genetics
Male
Regulatory T cells
T-Lymphocytes, Regulatory - metabolism
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Summary:Highlights • We analyzed the influence of IL-33 on Treg function In type 1 diabetes. • We analyzed the ability of IL-33 treated Tregs to inhibit the production of IFN-γ by effector lymphocytes in mixed cocultures. • IL-33 treatment of Tregs derived from patients with type 1 diabetes resulted in quantitative as well as qualitative changes in this cell population. • IL-33 may have immunoregulatory effect on Tregs.
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2017.04.011