Patterns of care and predictors of adjuvant therapies in elderly patients with glioblastoma: An analysis of the National Cancer Data Base

BACKGROUND The objectives of this study were to characterize patterns of care and to identify predictors for adjuvant therapy in elderly patients with glioblastoma in the modern era. METHODS. The National Cancer Data Base was queried for patients aged 70 years and older with glioblastoma diagnosed f...

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Bibliographic Details
Published in:Cancer 2017-09, Vol.123 (17), p.3277-3284
Main Authors: Amsbaugh, Mark J., Yusuf, Mehran B., Gaskins, Jeremy, Burton, Eric C., Woo, Shiao Y.
Format: Article
Language:English
Subjects:
Adjuvant therapy
Age
Age Factors
Aged
Aged, 80 and over
Brain cancer
Brain Neoplasms - mortality
Brain Neoplasms - pathology
Brain Neoplasms - therapy
Cancer
Cancer therapies
Chemoradiotherapy - methods
Chemotherapy
chemotherapy and radiation (CRT)
Cohort Studies
Combined Modality Therapy
Databases, Factual
Disease-Free Survival
elderly
Female
Geriatric Assessment
Geriatrics
Glioblastoma
Glioblastoma - mortality
Glioblastoma - pathology
Glioblastoma - therapy
Health risk assessment
Humans
Kaplan-Meier Estimate
Logistic Models
Male
Multivariate Analysis
Neoplasm Invasiveness - pathology
Neoplasm Staging
Neurosurgical Procedures - methods
Older people
Oncology
Patients
Predictive Value of Tests
Prognosis
Proportional Hazards Models
Radiation
Radiation therapy
Regression analysis
Retrospective Studies
Risk Assessment
Survival
Survival Analysis
Treatment Outcome
United States
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Summary:BACKGROUND The objectives of this study were to characterize patterns of care and to identify predictors for adjuvant therapy in elderly patients with glioblastoma in the modern era. METHODS. The National Cancer Data Base was queried for patients aged 70 years and older with glioblastoma diagnosed from January 1, 2004 through December 31, 2012. Multinomial logistic regression was used to identify predictors for receiving adjuvant therapy. Survival outcomes were estimated using the Kaplan‐Meier method and were analyzed using Cox regression models and the log‐rank test. RESULTS In total, 14,886 patients were identified. Of these, 8214 patients (55.2%) received combined‐modality therapy with chemotherapy and radiation (CRT), 3955 (26.6%) received no adjuvant therapy, 2065 (13.9%) received radiation therapy (RT) alone, and 652 (4.4%) received chemotherapy (CT) alone after undergoing resection. The receipt of CRT increased in frequency over the study interval, from 40.3% in 2004 to 59.8% in 2012. Younger patients (ages 70‐75 years) were more likely to receive CRT than no adjuvant therapy (P 
ISSN:0008-543X
1097-0142
DOI:10.1002/cncr.30730