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'Click cyclic ADP-ribose': a neutral second messenger mimic
Analogues of the potent Ca(2+) releasing second messenger cyclic ADP-ribose (cADPR) with a 1,2,3-triazole pyrophosphate bioisostere were synthesised by click-mediated macrocyclisation. The ability to activate Ca(2+) release was surprisingly retained, and hydrolysis of cADPR by CD38 could also be inh...
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Published in: | Chemical communications (Cambridge, England) England), 2014-01, Vol.50 (19), p.2458-2461 |
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Main Authors: | , , , , , |
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container_end_page | 2461 |
container_issue | 19 |
container_start_page | 2458 |
container_title | Chemical communications (Cambridge, England) |
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creator | Swarbrick, Joanna M Graeff, Richard Garnham, Clive Thomas, Mark P Galione, Antony Potter, Barry V L |
description | Analogues of the potent Ca(2+) releasing second messenger cyclic ADP-ribose (cADPR) with a 1,2,3-triazole pyrophosphate bioisostere were synthesised by click-mediated macrocyclisation. The ability to activate Ca(2+) release was surprisingly retained, and hydrolysis of cADPR by CD38 could also be inhibited, illustrating the potential of this approach to design drug-like signalling pathway modulators. |
doi_str_mv | 10.1039/c3cc49249d |
format | article |
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source | Royal Society of Chemistry |
subjects | Animals Calcium - metabolism Click Chemistry Cyclic ADP-Ribose - chemistry Cyclic ADP-Ribose - pharmacology Diphosphates - chemistry Female Hydrolysis Inhibition Modulators Ovum Pathways Releasing Sea Urchins Second Messenger Systems Signalling Synthesis |
title | 'Click cyclic ADP-ribose': a neutral second messenger mimic |
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