Chiral phosphoramide-catalyzed enantioselective synthesis of 2,3'-diindolylarylmethanes from indol-2-yl carbinols and indoles

We present the first asymmetric reaction of indol-2-yl carbinols with indole derivatives catalyzed by chiral phosphoramides for the enantioselective synthesis of 2,3'-diindolylarylmethanes in excellent yields of over 90% as well as high enantioselectivity of up to 96% ee.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2014-08, Vol.50 (62), p.8605-8608
Main Authors: Qi, Shuai, Liu, Chao-You, Ding, Jin-Ying, Han, Fu-She
Format: Article
Language:English
Subjects:
Asymmetry
Catalysis
Chemical reactions
Derivatives
Indoles
Indoles - chemical synthesis
Indoles - chemistry
Phosphoramides - chemistry
Stereoisomerism
Synthesis
Synthesis (chemistry)
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Description
Summary:We present the first asymmetric reaction of indol-2-yl carbinols with indole derivatives catalyzed by chiral phosphoramides for the enantioselective synthesis of 2,3'-diindolylarylmethanes in excellent yields of over 90% as well as high enantioselectivity of up to 96% ee.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc03605k