Rapid interrogation of the physical and chemical characteristics of salbutamol sulphate aerosol from a pressurised metered-dose inhaler (pMDI)

Individual micron-sized solid particles from a Salamol® pharmaceutical inhaler are stably captured in air using an optical trap for the first time. Raman spectroscopy of the levitated particles allows online interrogation of composition and deliquescent phase change within a high humidity environmen...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2014-12, Vol.50 (98), p.15499-15502
Main Authors: Tong, H-J, Fitzgerald, C, Gallimore, P J, Kalberer, M, Kuimova, M K, Seville, P C, Ward, A D, Pope, F D
Format: Article
Language:English
Subjects:
Administration, Inhalation
Aerosols
Aerosols - administration & dosage
Aerosols - chemistry
Albuterol - administration & dosage
Albuterol - chemistry
Bronchodilator Agents - administration & dosage
Bronchodilator Agents - chemistry
Humidity
Hygroscopicity
Inhalers
Interrogation
Nebulizers and Vaporizers
Particle Size
Phase change
Raman spectroscopy
Spectrum Analysis, Raman
Sulfates
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Summary:Individual micron-sized solid particles from a Salamol® pharmaceutical inhaler are stably captured in air using an optical trap for the first time. Raman spectroscopy of the levitated particles allows online interrogation of composition and deliquescent phase change within a high humidity environment that mimics the particle's travel from inhaler to lung.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc05803h