Direct oxidative nitration of aromatic sulfonamides under mild conditions

A direct nitration of aromatic sulfonamides using sodium nitrite as the nitrating agent has been developed. The reaction shows typically mono-substitution selectivity and can be enlarged to the gram scale with good yield.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2014-09, Vol.50 (69), p.9936-9938
Main Authors: Li, Ying-Xiu, Li, Lian-Hua, Yang, Yan-Fang, Hua, Hui-Liang, Yan, Xiao-Biao, Zhao, Lian-Biao, Zhang, Jin-Bang, Ji, Fa-Jin, Liang, Yong-Min
Format: Article
Language:English
Subjects:
Expansion
Nitration
Selectivity
Sodium nitrite
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Description
Summary:A direct nitration of aromatic sulfonamides using sodium nitrite as the nitrating agent has been developed. The reaction shows typically mono-substitution selectivity and can be enlarged to the gram scale with good yield.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc03784g