A simple access to N-(un)substituted isoquinolin-1(2H)-ones: unusual formation of regioisomeric isoquinolin-1(4H)-ones

A ligand/additive/Pd-free Cu-mediated coupling/cyclization strategy afforded the first practical, one-pot and general approach towards synthesis of N-(un)substituted isoquinolin-1(2H)-ones. Both the catalyst and the solvent used are recyclable. The use of the Cu reagent in excess led to the unusual...

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Published in:Chemical communications (Cambridge, England) England), 2014-06, Vol.50 (51), p.6797-6800
Main Authors: Chary, R Gangadhara, Dhananjaya, G, Prasad, K Vara, Vaishaly, S, Ganesh, Y S S, Dulla, Balakrishna, Kumar, K Shiva, Pal, Manojit
Format: Article
Language:English
Subjects:
Additives
Catalysis
Copper - chemistry
Coupling
Cyclization
Formations
Indicators and Reagents
Isomerism
Isoquinolines - chemical synthesis
Ligands
Magnetic Resonance Spectroscopy
Reagents
Solvents
Strategy
Synthesis
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creator Chary, R Gangadhara
Dhananjaya, G
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Vaishaly, S
Ganesh, Y S S
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Pal, Manojit
description A ligand/additive/Pd-free Cu-mediated coupling/cyclization strategy afforded the first practical, one-pot and general approach towards synthesis of N-(un)substituted isoquinolin-1(2H)-ones. Both the catalyst and the solvent used are recyclable. The use of the Cu reagent in excess led to the unusual formation of regioisomeric and uncommon isoquinolin-1(4H)-ones.
doi_str_mv 10.1039/c4cc01580k
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source Royal Society of Chemistry
subjects Additives
Catalysis
Copper - chemistry
Coupling
Cyclization
Formations
Indicators and Reagents
Isomerism
Isoquinolines - chemical synthesis
Ligands
Magnetic Resonance Spectroscopy
Reagents
Solvents
Strategy
Synthesis
title A simple access to N-(un)substituted isoquinolin-1(2H)-ones: unusual formation of regioisomeric isoquinolin-1(4H)-ones
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