Biomanufacturing Seamless Tubular and Hollow Collagen Scaffolds with Unique Design Features and Biomechanical Properties

A versatile process to develop designer collagen scaffolds for hollow and tubular tissue engineering applications is presented. This process creates seamless and biomechanically tunable scaffolds ranging from ureter‐like microsized tubings to structures with highly customized lumens that resemble in...

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Bibliographic Details
Published in:Advanced healthcare materials 2017-03, Vol.6 (5), p.np-n/a
Main Authors: Singh, Anirudha, Lee, David, Sopko, Nikolai, Matsui, Hotaka, Sabnekar, Praveena, Liu, Xiaopu, Elisseeff, Jennifer, Schoenberg, Mark P., Pienta, Kenneth, Bivalacqua, Trinity J.
Format: Article
Language:English
Subjects:
biomanufacturing
Biomechanics
Bioprosthesis
Biotechnology
collagen
Collagen - chemistry
Collagens
Customizing
Design engineering
Health care
Humans
Mesenchymal Stromal Cells - cytology
Mesenchymal Stromal Cells - metabolism
neo‐urinary bladders
neo‐urinary conduits
Scaffolds
Skin & tissue grafts
Stem cells
Tissue Scaffolds - chemistry
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Description
Summary:A versatile process to develop designer collagen scaffolds for hollow and tubular tissue engineering applications is presented. This process creates seamless and biomechanically tunable scaffolds ranging from ureter‐like microsized tubings to structures with highly customized lumens that resemble intestinal villi, fluid bladders, and alveolar sacs that together with stem cells can potentially be used in preclinical and clinical settings.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201601136