A highly versatile convergent/divergent "onion peel" synthetic strategy toward potent multivalent glycodendrimers

Both convergent and divergent strategies for the synthesis of "onion peel" glycodendrimers are reported which resulted in one of the best multivalent ligands known against the virulent factor from a bacterial lectin isolated from Pseudomonas aeruginosa.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2014-11, Vol.50 (87), p.13300-13303
Main Authors: Sharma, Rishi, Kottari, Naresh, Chabre, Yoann M, Abbassi, Leïla, Shiao, Tze Chieh, Roy, René
Format: Article
Language:English
Subjects:
Bacteria
Dendrimers - chemical synthesis
Dendrimers - chemistry
Dendrimers - pharmacology
Glycerides - chemical synthesis
Glycerides - chemistry
Glycerides - pharmacology
Lectins
Lectins - chemistry
Ligands
Molecular Structure
Onions
Pseudomonas aeruginosa
Pseudomonas aeruginosa - chemistry
Strategy
Synthesis
Virulence Factors - antagonists & inhibitors
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Description
Summary:Both convergent and divergent strategies for the synthesis of "onion peel" glycodendrimers are reported which resulted in one of the best multivalent ligands known against the virulent factor from a bacterial lectin isolated from Pseudomonas aeruginosa.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc06191h