Trifluoromethylation of arenediazonium salts with fluoroform-derived CuCF sub(3) in aqueous media

A new protocol has been developed for trifluoromethylation of arenediazonium salts with moisture-sensitive CuCF sub(3) (from fluoroform) in aqueous media. The reaction is governed by a radical mechanism, tolerates a broad variety of functional groups, and is applicable to the synthesis of complex, p...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2014-08, Vol.50 (71), p.10237-10240
Main Authors: Lishchynskyi, Anton, Berthon, Guillaume, Grushin, Vladimir V
Format: Article
Language:English
Subjects:
Fluoroform
Functional groups
Media
Organic chemistry
Radicals
Synthesis (chemistry)
Online Access:Get full text
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Summary:A new protocol has been developed for trifluoromethylation of arenediazonium salts with moisture-sensitive CuCF sub(3) (from fluoroform) in aqueous media. The reaction is governed by a radical mechanism, tolerates a broad variety of functional groups, and is applicable to the synthesis of complex, polyfunctionalized molecules.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc04930f