Amphiphilic phthalocyanine-cyclodextrin conjugates for cancer photodynamic therapy

Three phthalocyanines (Pcs) conjugated with α-, β- and γ-cyclodextrins (CDs) were prepared and their application as photosensitizer (PS) agents was assessed by photophysical, photochemical and in vitro photobiological studies. The photoactivity of Pc-α-CD and Pc-γ-CD ensures their potential as PDT d...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2014-08, Vol.50 (61), p.8363-8366
Main Authors: Lourenço, Leandro M O, Pereira, Patrícia M R, Maciel, Elisabete, Válega, Mónica, Domingues, Fernando M J, Domingues, Maria R M, Neves, Maria G P M S, Cavaleiro, José A S, Fernandes, Rosa, Tomé, João P C
Format: Article
Language:English
Subjects:
Bladder
Cancer
Cell Line
Cell Nucleus - chemistry
Cell Nucleus - pathology
Cell Survival - drug effects
Conjugates
Cyclodextrins - chemistry
Drugs
Humans
Indoles - chemistry
Light
Microscopy, Fluorescence
Photochemotherapy
Photodynamic therapy
Photosensitizing Agents - chemical synthesis
Photosensitizing Agents - therapeutic use
Photosensitizing Agents - toxicity
Urinary Bladder Neoplasms - drug therapy
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Summary:Three phthalocyanines (Pcs) conjugated with α-, β- and γ-cyclodextrins (CDs) were prepared and their application as photosensitizer (PS) agents was assessed by photophysical, photochemical and in vitro photobiological studies. The photoactivity of Pc-α-CD and Pc-γ-CD ensures their potential as PDT drugs against UM-UC-3 human bladder cancer cells.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc02226b