Evaluation of a New Biosensor Based on in Situ Synthesized PPy-Ag-PVP Nanohybrid for Selective Detection of Dopamine

In the present work, in situ synthesis of polypyrrole-silver-polyvinylpyrrolidone (PPy-Ag-PVP) nanohybrid using AgNO3 as an oxidant and polyvinylpyrrolidone (PVP) as a stabilizer and surfactant is demonstrated. The obtained ternary PPy-Ag-PVP nanohybrid was characterized by UV–vis, FT-IR, XRD, Raman...

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Bibliographic Details
Published in:The journal of physical chemistry. B 2017-02, Vol.121 (5), p.1118-1127
Main Authors: Vellaichamy, Balakumar, Periakaruppan, Prakash, Paulmony, Tharmaraj
Format: Article
Language:English
Subjects:
Dopamine
Electrodes
Glassy carbon
Nanostructure
Physical chemistry
Polyvinylpyrrolidone
Synthesis
Urine
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Summary:In the present work, in situ synthesis of polypyrrole-silver-polyvinylpyrrolidone (PPy-Ag-PVP) nanohybrid using AgNO3 as an oxidant and polyvinylpyrrolidone (PVP) as a stabilizer and surfactant is demonstrated. The obtained ternary PPy-Ag-PVP nanohybrid was characterized by UV–vis, FT-IR, XRD, Raman, TGA, SEM, and HR-TEM analysis. Further the synthesized PPy-Ag-PVP has been investigated for its selective and sensitive sensing of dopamine (DA). The PPy-Ag-PVP modified glassy carbon electrode shows a reversible electrochemical behavior with superior response for DA. The limit of detection and limit of quantification are found to be 0.0126 and 0.042 μM (S/N = 3 and 10), respectively, with remarkable sensitivity (7.26 μA mM–1 cm–2). The practical application of the present modified electrode has been validated by determining the concentration of DA in human urine samples of different age group.
ISSN:1520-6106
1520-5207
DOI:10.1021/acs.jpcb.6b11225