A new and potentially prebiotic α-cytidine derivative

A new α-cytidine derivative was synthesised from the prebiotic reaction of ribose aminooxazoline and dicyanoacetylene. The tetracyclic structure of the product was confirmed by X-ray diffraction and then an alternative 6-step synthetic pathway to the product was found which was suitable for large-sc...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2017-03, Vol.53 (23), p.3327-3329
Main Authors: Tsanakopoulou, Maria, Xu, Jianfeng, Bond, Andrew D, Sutherland, John D
Format: Article
Language:English
Subjects:
Derivatives
Pathways
Ribose
Synthesis
Synthesis (chemistry)
X ray diffraction
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Summary:A new α-cytidine derivative was synthesised from the prebiotic reaction of ribose aminooxazoline and dicyanoacetylene. The tetracyclic structure of the product was confirmed by X-ray diffraction and then an alternative 6-step synthetic pathway to the product was found which was suitable for large-scale synthesis.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc00693d