A photoCORM nanocarrier for CO release using NIR light

A water-soluble nanocarrier for a photo-activated CO releasing moiety (photoCORM) that can be triggered with NIR excitation is described. This has an upconversion nanoparticle core encapsulated by an amphiphilic polymer imparting both water solubility and a hydrophobic interior containing the photoC...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2015-01, Vol.51 (11), p.2072-2075
Main Authors: Pierri, Agustin E, Huang, Po-Ju, Garcia, John V, Stanfill, James G, Chui, Megan, Wu, Guang, Zheng, Nanfeng, Ford, Peter C
Format: Article
Language:English
Subjects:
Carbon Monoxide - chemistry
Drug Carriers - chemistry
Drug Liberation
Encapsulation
Excitation
Hydrophobic and Hydrophilic Interactions
Infrared Rays
Models, Molecular
Molecular Conformation
Nanostructure
Nanostructures - chemistry
Releasing
Solubility
Strategy
Upconversion
Water - chemistry
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Description
Summary:A water-soluble nanocarrier for a photo-activated CO releasing moiety (photoCORM) that can be triggered with NIR excitation is described. This has an upconversion nanoparticle core encapsulated by an amphiphilic polymer imparting both water solubility and a hydrophobic interior containing the photoCORM trans-Mn(bpy)(PPh3)2(CO)2. Such an ensemble offers a unique strategy for CO delivery to biological targets.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc06766e