A phthalimidation protocol that follows protein defined parameters

This work outlines the first phthalimidation protocol suitable for protein labeling and performed in aqueous media at room temperature and neutral pH with no catalyst or co-reagent required. The methodology is suitable for a range of amines and its efficiency was determined with chemoselective and s...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2015-01, Vol.51 (3), p.473-476
Main Authors: Singudas, Rohith, Adusumalli, Srinivasa Rao, Joshi, Pralhad Namdev, Rai, Vishal
Format: Article
Language:English
Subjects:
Amines
Amines - chemistry
Catalysts
Efficiency
Hydrogen-Ion Concentration
Labels
Marking
Parameters
Phthalimides - chemistry
Proteins
Proteins - chemistry
Staining and Labeling - methods
Temperature
Water - chemistry
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Summary:This work outlines the first phthalimidation protocol suitable for protein labeling and performed in aqueous media at room temperature and neutral pH with no catalyst or co-reagent required. The methodology is suitable for a range of amines and its efficiency was determined with chemoselective and site-selective protein labeling.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc08503e