Few‐Layer Graphene Kills Selectively Tumor Cells from Myelomonocytic Leukemia Patients

In the cure of cancer, a major cause of today's mortality, chemotherapy is the most common treatment, though serious frequent challenges are encountered by current anticancer drugs. We discovered that few‐layer graphene (FLG) dispersions have a specific killer action on monocytes, showing neith...

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Bibliographic Details
Published in:Angewandte Chemie 2017-03, Vol.129 (11), p.3060-3065
Main Authors: Russier, Julie, León, Verónica, Orecchioni, Marco, Hirata, Eri, Virdis, Patrizia, Fozza, Claudio, Sgarrella, Francesco, Cuniberti, Gianaurelio, Prato, Maurizio, Vázquez, Ester, Bianco, Alberto, Delogu, Lucia G.
Format: Article
Language:English
Subjects:
Antineoplastic drugs
Antitumor agents
Cancer
Cancer therapies
Cell activation
Chemistry
Chemotherapy
Dispersions
Drugs
Etoposide
Graphen
Graphene
Immune system
Immune systems
Immunosuppressive agents
Immunsystem
Krebstherapie
Leukemia
Leukemias
Monocytes
Myelomonocytic leukemia
Myelomonozytäre Leukämie
Nanomaterialien
Toxicity
Tumor cells
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Summary:In the cure of cancer, a major cause of today's mortality, chemotherapy is the most common treatment, though serious frequent challenges are encountered by current anticancer drugs. We discovered that few‐layer graphene (FLG) dispersions have a specific killer action on monocytes, showing neither toxic nor activation effects on other immune cells. We confirmed the therapeutic application of graphene on an aggressive type of cancer that is myelomonocytic leukemia, where the monocytes are in their malignant form. We demonstrated that graphene has the unique ability to target and boost specifically the necrosis of monocytic cancer cells. Moreover, the comparison between FLG and a common chemotherapeutic drug, etoposide, confirmed the higher specificity and toxicity of FLG. Since current chemotherapy treatments of leukemia still cause serious problems, these findings open the way to new and safer therapeutic approaches. Graphen‐basiertes Krebsmittel: Ein spezifischer zytotoxischer Effekt von Graphen‐Mehrfachschichten auf primäre humane Monozyten wurde entdeckt. Diese neue biologische Eigenschaft von Graphen wurde zur Therapie von Krebs genutzt. Graphen steigert zielgerichtet und erfolgreich die Nekrose von monozytoiden Krebszellen bei Patienten mit akuter myeloischer sowie chronischer myelomonozytärer Leukämie.
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.201700078