Reversible conformational changes in the parallel type G-quadruplex structure inside a thermoresponsive hydrogel

The novel property of reversible regulation of parallel type G-quadruplexes with moderate temperature changes was discovered in thermoresponsive hydrogels using a universal chiroptical spectrophotometer 1 (UCS-1). This study is the first to report the regulation of the ssDNA steric structure by usin...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2017, Vol.53 (21), p.3142-3144
Main Authors: Hasuike, Erika, Akimoto, Aya Mizutani, Kuroda, Reiko, Matsukawa, Ko, Hiruta, Yuki, Kanazawa, Hideko, Yoshida, Ryo
Format: Article
Language:English
Subjects:
Control
Hydrogels
Spectrophotometers
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Summary:The novel property of reversible regulation of parallel type G-quadruplexes with moderate temperature changes was discovered in thermoresponsive hydrogels using a universal chiroptical spectrophotometer 1 (UCS-1). This study is the first to report the regulation of the ssDNA steric structure by using a poly(N-isopropylacrylamide) (PNIPAAm) gel.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc00279c