Assessing dimerisation degree and cooperativity in a biomimetic small-molecule model by pulsed EPR

Pulsed electron paramagnetic resonance (EPR) spectroscopy is gaining increasing importance as a complementary biophysical technique in structural biology. Here, we describe the synthesis, optimisation, and EPR titration studies of a spin-labelled terpyridine Zn(II) complex serving as a small-molecul...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2015-03, Vol.51 (25), p.5257-5260
Main Authors: Ackermann, K, Giannoulis, A, Cordes, D B, Slawin, A M Z, Bode, B E
Format: Article
Language:English
Subjects:
Biology
Biomimetic Materials - chemical synthesis
Biomimetic Materials - chemistry
Biomimetics
Crystallography, X-Ray
Electron paramagnetic resonance
Electron Spin Resonance Spectroscopy
Mathematical models
Models, Molecular
Molecular Structure
Optimization
Organometallic Compounds - chemical synthesis
Organometallic Compounds - chemistry
Pyridines - chemistry
Spectroscopy
Synthesis
Titration
Zinc - chemistry
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Summary:Pulsed electron paramagnetic resonance (EPR) spectroscopy is gaining increasing importance as a complementary biophysical technique in structural biology. Here, we describe the synthesis, optimisation, and EPR titration studies of a spin-labelled terpyridine Zn(II) complex serving as a small-molecule model system for tuneable dimerisation.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc08656b