Inorganic nanoparticles as nucleic acid transporters into eukaryotic cells

The review is concerned with inorganic nanoparticles (gold, titanium dioxide, silica, iron oxides, calcium phosphate) used as nucleic acid transporters into mammalian cells. Methods for the synthesis of nanoparticles and approaches to surface modification through covalent or noncovalent attachment o...

Full description

Saved in:
Bibliographic Details
Published in:Russian chemical reviews 2017-01, Vol.86 (2), p.113-127
Main Authors: Amirkhanov, Rinat N., Zarytova, Valentina F., Zenkova, Marina A.
Format: Article
Language:English
Subjects:
Calcium phosphate
Calcium phosphates
Conjugates
Covalence
Iron oxides
Lime
Mammals
Nanoparticles
Nucleic acids
Silicon dioxide
Survival
Titanium dioxide
Uptakes
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The review is concerned with inorganic nanoparticles (gold, titanium dioxide, silica, iron oxides, calcium phosphate) used as nucleic acid transporters into mammalian cells. Methods for the synthesis of nanoparticles and approaches to surface modification through covalent or noncovalent attachment of low- or high-molecular-weight compounds are considered. The data available from the literature on biological action of nucleic acids delivered into the cells by nanoparticles and on the effect of nanoparticles and their conjugates and complexes on the cell survival are summarized. Pathways of cellular internalization of nanoparticles and the mechanism of their excretion, as well as the ways of release of nucleic acids from their complexes with nanoparticles after the cellular uptake are described.
ISSN:0036-021X
1468-4837
DOI:10.1070/RCR4604