Design, synthesis, characterization and biological studies of copper(II) complexes with 2‐aminobenzimidazole derivatives as biomimetic agents

Four novel copper(II) complexes of 2‐aminobenzimidazole derivatives (obtained from the Knoevenagel condensation of acetylacetone (obtained from acetylacetone and halogen‐substituted benzaldehydes) and 2‐aminobenzimidazole) were synthesized. They were characterized using elemental analysis, molar con...

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Bibliographic Details
Published in:Applied organometallic chemistry 2017-04, Vol.31 (4), p.np-n/a
Main Authors: Joseph, J., Suman, A., Balakrishnan, Nisha
Format: Article
Language:English
Subjects:
Acetylacetone
Aminobenzimidazole
Antiinfectives and antibacterials
Antimicrobial
antioxidant
Antioxidants
Biomimetics
Chemistry
complexes
Condensation
Coordination compounds
Copper
Copper compounds
Deoxyribonucleic acid
Derivatives
Distortion
DNA
DNA binding
Electron bombardment
Electron paramagnetic resonance
Fourier analysis
Fourier transforms
Infrared spectroscopy
Ligands
NMR
Nuclear magnetic resonance
Resistance
Schiff base
Superoxide dismutase
Synthesis
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Summary:Four novel copper(II) complexes of 2‐aminobenzimidazole derivatives (obtained from the Knoevenagel condensation of acetylacetone (obtained from acetylacetone and halogen‐substituted benzaldehydes) and 2‐aminobenzimidazole) were synthesized. They were characterized using elemental analysis, molar conductance measurements, and fast atom bombardment mass, Fourier transform infrared, NMR, UV–visible and electron paramagnetic resonance spectroscopies. On the basis of the spectral studies, a distorted square planar geometry was assigned for all the complexes. The antibacterial screening of the ligands and their complexes revealed that all the complexes had higher activities than the free ligands. Superoxide dismutase and antioxidant activities of the copper complexes were also studied. The shifts in ΔEp, E1/2, Ipc and Ipa values were explored for the interaction of the complexes with calf thymus DNA using the electrochemical technique. Antibacterial screening revealed that all the complexes showed higher activities than the free ligands. Superoxide dismutase and antioxidant activities of the copper complexes were also studied. The shift in ΔEp, E1/2, Ipc and Ipa values were explored for the interaction of the complexes with calf thymus DNA using the electrochemical technique.
ISSN:0268-2605
1099-0739
DOI:10.1002/aoc.3585