Design, synthesis, characterization and biological studies of copper(II) complexes with 2‐aminobenzimidazole derivatives as biomimetic agents

• Published in: Applied organometallic chemistry 2017-04, Vol.31 (4), p.np-n/a
• Main Authors: Joseph, J., Suman, A., Balakrishnan, Nisha
• Format: Article
• Language: English
• Subjects: Acetylacetone; Aminobenzimidazole; Antiinfectives and antibacterials; Antimicrobial; antioxidant; Antioxidants; Biomimetics; Chemistry; complexes; Condensation; Coordination compounds; Copper; Copper compounds; Deoxyribonucleic acid; Derivatives; Distortion; DNA; DNA binding; Electron bombardment; Electron paramagnetic resonance; Fourier analysis; Fourier transforms; Infrared spectroscopy; Ligands; NMR; Nuclear magnetic resonance; Resistance; Schiff base; Superoxide dismutase; Synthesis
• ISSN: 0268-2605; 1099-0739
• DOI: 10.1002/aoc.3585

Four novel copper(II) complexes of 2‐aminobenzimidazole derivatives (obtained from the Knoevenagel condensation of acetylacetone (obtained from acetylacetone and halogen‐substituted benzaldehydes) and 2‐aminobenzimidazole) were synthesized. They were characterized using elemental analysis, molar conductance measurements, and fast atom bombardment mass, Fourier transform infrared, NMR, UV–visible and electron paramagnetic resonance spectroscopies. On the basis of the spectral studies, a distorted square planar geometry was assigned for all the complexes. The antibacterial screening of the ligands and their complexes revealed that all the complexes had higher activities than the free ligands. Superoxide dismutase and antioxidant activities of the copper complexes were also studied. The shifts in ΔEp, E1/2, Ipc and Ipa values were explored for the interaction of the complexes with calf thymus DNA using the electrochemical technique. Antibacterial screening revealed that all the complexes showed higher activities than the free ligands. Superoxide dismutase and antioxidant activities of the copper complexes were also studied. The shift in ΔEp, E1/2, Ipc and Ipa values were explored for the interaction of the complexes with calf thymus DNA using the electrochemical technique.