The association of eight potentially functional polymorphisms in five adrenergic receptor-encoding genes with myocardial infarction risk in Han Chinese

Adrenergic receptors play a key role in activating the sympathetic nervous system, which often accompanies with the development of myocardial infarction (MI). Here, we aimed to test the association of eight potentially functional polymorphisms in five adrenergic receptor-encoding genes with MI risk....

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Bibliographic Details
Published in:Gene 2017-08, Vol.624, p.43-49
Main Authors: Xia, Kun, Ding, Rongjing, Zhang, Zhiyong, Li, Weiming, Shang, Xiaoming, Yang, Xinchun, Wang, Lefeng, Zhang, Qi
Format: Article
Language:English
Subjects:
Adrenergic receptor
Adult
Aged
Blood Pressure - genetics
Case-Control Studies
Cholesterol, HDL - blood
Cholesterol, HDL - genetics
Female
Humans
Interaction
Male
Middle Aged
Myocardial infarction
Myocardial Infarction - diagnosis
Myocardial Infarction - genetics
Nomogram
Polymorphism
Polymorphism, Single Nucleotide
Receptors, Adrenergic, alpha - genetics
Receptors, Adrenergic, beta - genetics
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Summary:Adrenergic receptors play a key role in activating the sympathetic nervous system, which often accompanies with the development of myocardial infarction (MI). Here, we aimed to test the association of eight potentially functional polymorphisms in five adrenergic receptor-encoding genes with MI risk. Genotypes were available for 717 MI patients and 612 controls. There were no detectable deviations from the Hardy-Weinberg equilibrium for all study polymorphisms. Allele frequencies differed remarkably for ADRA2B D/I (P
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2017.04.045