Adrenic acid as an inflammation enhancer in non-alcoholic fatty liver disease

This study was designed to identify novel links between lipid species and disease progression in non-alcoholic fatty liver disease (NAFLD). We analyzed lipid species in the liver and plasma of db/db mice fed a choline-deficient l-amino acid-defined, high-fat diet (CDAHFD) using liquid chromatography...

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Bibliographic Details
Published in:Archives of biochemistry and biophysics 2017-06, Vol.623-624, p.64-75
Main Authors: Horas H Nababan, Saut, Nishiumi, Shin, Kawano, Yuki, Kobayashi, Takashi, Yoshida, Masaru, Azuma, Takeshi
Format: Article
Language:English
Subjects:
Adrenic acid
Adult
Alanine aminotransferase
Animals
Chemokine
Cytokines - analysis
Cytokines - immunology
Disease Models, Animal
Disease Progression
Fatty Acids, Unsaturated - analysis
Fatty Acids, Unsaturated - blood
Fatty Acids, Unsaturated - immunology
Female
Gene Expression Regulation
Hep G2 Cells
Humans
Inflammation - blood
Inflammation - genetics
Inflammation - immunology
Inflammation - pathology
Inflammation Mediators - analysis
Inflammation Mediators - blood
Inflammation Mediators - immunology
Lipids - analysis
Lipids - blood
Lipids - immunology
Liquid chromatography/mass-spectrometry
Liver - immunology
Liver - pathology
Male
Mice
Mice, Inbred C57BL
Middle Aged
Non-alcoholic fatty liver disease
Non-alcoholic Fatty Liver Disease - blood
Non-alcoholic Fatty Liver Disease - genetics
Non-alcoholic Fatty Liver Disease - immunology
Non-alcoholic Fatty Liver Disease - pathology
Oxidative Stress
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Summary:This study was designed to identify novel links between lipid species and disease progression in non-alcoholic fatty liver disease (NAFLD). We analyzed lipid species in the liver and plasma of db/db mice fed a choline-deficient l-amino acid-defined, high-fat diet (CDAHFD) using liquid chromatography/mass spectrometry (LC/MS). An in vitro experiment was performed using HepG2 cells stimulated with recombinant human TNFα or IL1β. The expression of steatosis-, inflammation-, and fibrosis-related genes were analyzed. Plasma samples from NAFLD patients were also analyzed by LC/MS. The CDAHFD-fed db/db mice with hepatic steatosis, inflammation, mild fibrosis, obesity, and hypercholesterolemia displayed significantly higher hepatic and plasma levels of free adrenic acid (p 
ISSN:0003-9861
1096-0384
DOI:10.1016/j.abb.2017.04.009